Literature DB >> 20188663

StIKKing together: do multiple IKK pathways cooperate in the DNA-damage response?

David F Allison1, Marty W Mayo.   

Abstract

Although IKK-related kinases are known to augment immune pathways, their importance to DNA-damage response has not been previously elucidated; in this issue of Molecular Cell, Renner et al. (2010) show that genotoxic stress requires SUMOylated IKKvarepsilon to regulate NF-kappaB transcription and cell survival. Copyright 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID: 20188663     DOI: 10.1016/j.molcel.2010.02.004

Source DB:  PubMed          Journal:  Mol Cell        ISSN: 1097-2765            Impact factor:   17.970


  2 in total

1.  Local administration of IKK small molecule inhibitor may enhance fracture healing in osteoporosis patient.

Authors:  Duanyang Han; Peixun Zhang; Baoguo Jiang
Journal:  Int J Clin Exp Med       Date:  2015-01-15

2.  NF-κB inhibits osteogenic differentiation of mesenchymal stem cells by promoting β-catenin degradation.

Authors:  Jia Chang; Fei Liu; Min Lee; Benjamin Wu; Kang Ting; Janette N Zara; Chia Soo; Khalid Al Hezaimi; Weiping Zou; Xiaohong Chen; David J Mooney; Cun-Yu Wang
Journal:  Proc Natl Acad Sci U S A       Date:  2013-05-20       Impact factor: 11.205

  2 in total

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