Literature DB >> 20188575

SAR and molecular mechanism study of novel acylhydrazone compounds targeting HIV-1 CA.

Yinxue Jin1, Zhiwu Tan1, Meizi He1, Baohe Tian1, Shixing Tang2, Indira Hewlett2, Ming Yang1.   

Abstract

We synthesized a series of acylhydrazone compounds bearing naturally occurring amino acids' side chains as HIV assembly inhibitors. Biological evaluation indicated that the compounds had anti-SIV and capsid assembly inhibitory activities. The structure-activity relationship (SAR) study showed that compounds bearing proper aromatic side chains had potential antiviral activities. The molecular modeling experiments revealed the molecular mechanism that they could bind to CA in the same manner as CAP-1 and occupy two more grooves. Copyright 2010. Published by Elsevier Ltd.

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Year:  2010        PMID： 20188575     DOI： 10.1016/j.bmc.2010.02.003

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  8 in total

1.  Inhibiting early-stage events in HIV-1 replication by small-molecule targeting of the HIV-1 capsid.

Authors:  Sandhya Kortagere; Navid Madani; Marie K Mankowski; Arne Schön; Isaac Zentner; Gokul Swaminathan; Amy Princiotto; Kevin Anthony; Apara Oza; Luz-Jeannette Sierra; Shendra R Passic; Xiaozhao Wang; David M Jones; Eric Stavale; Fred C Krebs; Julio Martín-García; Ernesto Freire; Roger G Ptak; Joseph Sodroski; Simon Cocklin; Amos B Smith
Journal:  J Virol       Date:  2012-05-30       Impact factor: 5.103

2.  In vitro anti-HIV-1 activity of salicylidene acylhydrazide compounds.

Authors:  Donald N Forthal; Tran B Phan; Anatoly V Slepenkin; Gary Landucci; Hencelyn Chu; Mikael Elofsson; Ellena Peterson
Journal:  Int J Antimicrob Agents       Date:  2012-07-20       Impact factor: 5.283

Review 3.  HIV-1 Gag as an Antiviral Target: Development of Assembly and Maturation Inhibitors.

Authors:  Paul Spearman
Journal:  Curr Top Med Chem       Date:  2016       Impact factor: 3.295

Review 4.  Therapeutic potential of hydrazones as anti-inflammatory agents.

Authors:  Anu Kajal; Suman Bala; Neha Sharma; Sunil Kamboj; Vipin Saini
Journal:  Int J Med Chem       Date:  2014-03-04

5.  Comparison of Biochemical Properties of HIV-1 and HIV-2 Capsid Proteins.

Authors:  Yasuyuki Miyazaki; Ariko Miyake; Noya Doi; Takaaki Koma; Tsuneo Uchiyama; Akio Adachi; Masako Nomaguchi
Journal:  Front Microbiol       Date:  2017-06-13       Impact factor: 5.640

6.  (R)-2-Phenyl-4,5-Dihydrothiazole-4-Carboxamide Derivatives Containing a Diacylhydrazine Group: Synthesis, Biological Evaluation, and SARs.

Authors:  Feng-Yun Li; Jing-Bo Liu; Jia-Ning Gong; Gen Li
Journal:  Molecules       Date:  2019-12-04       Impact factor: 4.411

7.  Structure-activity relationships of a novel capsid targeted inhibitor of HIV-1 replication.

Authors:  Sandhya Kortagere; Jimmy P Xu; Marie K Mankowski; Roger G Ptak; Simon Cocklin
Journal:  J Chem Inf Model       Date:  2014-10-28       Impact factor: 4.956

8.  A Cell Internalizing Antibody Targeting Capsid Protein (p24) Inhibits the Replication of HIV-1 in T Cells Lines and PBMCs: A Proof of Concept Study.

Authors:  Syed A Ali; Sin-Yeang Teow; Tasyriq Che Omar; Alan Soo-Beng Khoo; Tan Soo Choon; Narazah Mohd Yusoff
Journal:  PLoS One       Date:  2016-01-07       Impact factor: 3.240
  8 in total

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