Kutluk Oktay1, Kenny A Rodriguez-Wallberg, Gulnaz Sahin. 1. Institute for Fertility Preservation, Department of Obstetrics and Gynecology, NY Medical College-Westchester Medical Center, Valhalla, New York 10595, USA. koktay@fertilitypreservation.org
Abstract
OBJECTIVE: To report a novel approach to fertility preservation in adolescents with Turner syndrome mosaicism by repeated controlled ovarian stimulation and oocyte cryopreservation. DESIGN: Case report. SETTING: Academic reproductive medicine center. PATIENT(S): Fourteen-year-old adolescent diagnosed with Turner syndrome mosaicism. INTERVENTION(S): Two cyles of controlled ovarian stimulation and oocyte cryopreservation within 1 year. MAIN OUTCOME MEASURE(S): Recovery of oocytes after controlled ovarian stimulation and oocyte cryopreservation. RESULT(S): Eleven oocytes were retrieved, of which eight were mature and three were immature during the first cycle. One year later, four mature and three immature oocytes were retrieved after a treatment cycle with even higher gonadotropin doses. All oocytes were cryopreserved by vitrification. CONCLUSION(S): Controlled ovarian stimulation and oocyte cryopreservation may be an option for fertility preservation in selected adolescents with Turner syndrome mosaicism and impending ovarian failure. Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
OBJECTIVE: To report a novel approach to fertility preservation in adolescents with Turner syndrome mosaicism by repeated controlled ovarian stimulation and oocyte cryopreservation. DESIGN: Case report. SETTING: Academic reproductive medicine center. PATIENT(S): Fourteen-year-old adolescent diagnosed with Turner syndrome mosaicism. INTERVENTION(S): Two cyles of controlled ovarian stimulation and oocyte cryopreservation within 1 year. MAIN OUTCOME MEASURE(S): Recovery of oocytes after controlled ovarian stimulation and oocyte cryopreservation. RESULT(S): Eleven oocytes were retrieved, of which eight were mature and three were immature during the first cycle. One year later, four mature and three immature oocytes were retrieved after a treatment cycle with even higher gonadotropin doses. All oocytes were cryopreserved by vitrification. CONCLUSION(S): Controlled ovarian stimulation and oocyte cryopreservation may be an option for fertility preservation in selected adolescents with Turner syndrome mosaicism and impending ovarian failure. Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Authors: L Strypstein; E Van Moer; J Nekkebroeck; I Segers; H Tournaye; I Demeestere; M-M Dolmans; W Verpoest; M De Vos Journal: J Assist Reprod Genet Date: 2022-02-05 Impact factor: 3.412
Authors: Sharrόn L Manuel; Molly B Moravek; Rafael Confino; Kristin N Smith; Angela K Lawson; Susan C Klock; Mary Ellen Pavone Journal: J Assist Reprod Genet Date: 2019-12-11 Impact factor: 3.412