| Literature DB >> 20188355 |
María Eugenia Matzkin1, Artur Mayerhofer, Soledad Paola Rossi, Betina Gonzalez, Candela Rocío Gonzalez, Silvia Inés Gonzalez-Calvar, Claudio Terradas, Roberto Ponzio, Elisa Puigdomenech, Oscar Levalle, Ricardo Saúl Calandra, Mónica Beatriz Frungieri.
Abstract
As we previously reported, testes of men suffering from hypospermatogenesis and germ cell arrest or Sertoli cell-only syndrome show a major increase in the number of macrophages expressing interleukin-1β (IL-1β) and abundant expression of cyclooxygenase-2 (COX-2), the inducible isoform of the key enzyme in the biosynthesis of prostaglandins (PGs), in Leydig cells. In the present study we report [1] a positive correlation between IL-1β levels and COX-2 expression in testes of infertile patients, [2] the induction of COX-2 by IL-1β in mouse Leydig cells (TM3) and human macrophages (THP-1), and therefore [3] evidence for an IL-1β-dependent induction of testicular inflammatory states.Entities:
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Year: 2010 PMID： 20188355 DOI： 10.1016/j.fertnstert.2010.01.039
Source DB: PubMed Journal: Fertil Steril ISSN： 0015-0282 Impact factor: 7.329