| Literature DB >> 20188099 |
Alexander Hayward1, Tokiharu Takahashi, William G Bendena, Stephen S Tobe, Jerome H L Hui.
Abstract
Vitellogenins and other large lipid transfer proteins (LLTP) are well known to play significant roles in the development, metabolism and reproduction of animals. Comparative genomics and phylogenetic analyses of LLTPs using the most comprehensive dataset in metazoans to date are carried out. Our analyses demonstrate that LLTP genes arose significantly earlier, and are more widespread than previously proposed - being present in numerous additional bilaterian and non-bilaterian lineages. A hypothesis is advanced that the most ancestral animal LLTP gene is Vtg, while loss of domains occurred at the bilaterians stem giving rise to apolipoprotein and microsomal triglyceride transfer proteins genes. Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.Entities:
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Year: 2010 PMID： 20188099 DOI： 10.1016/j.febslet.2010.02.056
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124