BACKGROUND: Angiogenesis plays an important role in tumor progression. The vascular endothelial growth factor (VEGF) is an important regulator of angiogenesis. In the present study we evaluated single nucleotide polymorphisms (SNPs) -2578C > A, -1154G > A, and +936C > T in the VEGF gene, and their prognostic value for patients operated on for colorectal cancer (CRC). PATIENTS AND METHOD: VEGF polymorphisms have been analyzed in 177 patients who had undergone surgical resection at Hospital Clínico San Carlos. The analysis of these polymorphisms was performed with specific probes for each nucleotide in a multiplex reaction using real-time PCR. RESULTS: We only found a statistically significant relationship for one of these three polymorphisms, +936C > T, with gender and tumor location; 10.7% of patients heterozygotes for this SNP had tumors located in proximal colon, 35.2% in distal segment and 54.1% in rectum (p = 0.03). Patients with the +936T/T genotype had 100% overall survival (OS). CONCLUSION: Patients with a +936T/T genotype showed increased survival, therefore the +936C > T SNP could be a useful marker in the follow-up and clinical management of patients with colorectal cancer.
BACKGROUND: Angiogenesis plays an important role in tumor progression. The vascular endothelial growth factor (VEGF) is an important regulator of angiogenesis. In the present study we evaluated single nucleotide polymorphisms (SNPs) -2578C > A, -1154G > A, and +936C > T in the VEGF gene, and their prognostic value for patients operated on for colorectal cancer (CRC). PATIENTS AND METHOD:VEGF polymorphisms have been analyzed in 177 patients who had undergone surgical resection at Hospital Clínico San Carlos. The analysis of these polymorphisms was performed with specific probes for each nucleotide in a multiplex reaction using real-time PCR. RESULTS: We only found a statistically significant relationship for one of these three polymorphisms, +936C > T, with gender and tumor location; 10.7% of patients heterozygotes for this SNP had tumors located in proximal colon, 35.2% in distal segment and 54.1% in rectum (p = 0.03). Patients with the +936T/T genotype had 100% overall survival (OS). CONCLUSION:Patients with a +936T/T genotype showed increased survival, therefore the +936C > T SNP could be a useful marker in the follow-up and clinical management of patients with colorectal cancer.
Authors: Moon Ju Jang; Jong Woo Kim; Young Joo Jeon; So Young Chong; Doyeun Oh; Nam Keun Kim Journal: Int J Clin Oncol Date: 2012-11-07 Impact factor: 3.402
Authors: Renate S Olsen; Mikael Lindh; Emina Vorkapic; Roland E Andersson; Niklas Zar; Sture Löfgren; Jan Dimberg; Andreas Matussek; Dick Wågsäter Journal: Int J Colorectal Dis Date: 2015-05-26 Impact factor: 2.571
Authors: Maria Eduarda Lopes Baitello; Graciele Domitila Tenani; Rafael Fernandes Ferreira; Victor Nogueira; Marcela Augusta de Souza Pinhel; Rita de Cássia Martins Alves da Silva; Renato Ferreira da Silva; Patrícia da Silva Fucuta; Moacir Fernandes de Godoy; Dorotéia Rossi Silva Souza Journal: Can J Gastroenterol Hepatol Date: 2016-08-31