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Literature DB >> 20187257

Protein degradation, aggregation, and misfolding.

Ana Maria Cuervo¹, Esther S P Wong, Marta Martinez-Vicente.

Abstract

The cellular surveillance systems guarantee proper removal of altered components from inside cells. Alterations of these systems in neurons have been proposed to be involved in the pathogenesis of different neurodegenerative disorders. In this review, we comment on the advances in our current understanding of how changes in the intracellular proteolytic systems, the main components of the cellular quality control system, contribute to neurodegeneration, with special emphasis on Parkinson's disease.

Entities: Disease

Mesh：

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Year: 2010 PMID： 20187257 DOI： 10.1002/mds.22718

Source DB: PubMed Journal: Mov Disord ISSN： 0885-3185 Impact factor: 10.338

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Cited

41 in total

1. Redox control of 20S proteasome gating.

Authors: Gustavo M Silva; Luis E S Netto; Vanessa Simões; Luiz F A Santos; Fabio C Gozzo; Marcos A A Demasi; Cristiano L P Oliveira; Renata N Bicev; Clécio F Klitzke; Mari C Sogayar; Marilene Demasi
Journal: Antioxid Redox Signal Date: 2012-03-06 Impact factor: 8.401

2. The ubiquitin E3 ligase parkin regulates the proapoptotic function of Bax.

Authors: Bethann N Johnson; Alison K Berger; Giuseppe P Cortese; Matthew J Lavoie
Journal: Proc Natl Acad Sci U S A Date: 2012-03-29 Impact factor: 11.205

Review 3. Sorting out release, uptake and processing of alpha-synuclein during prion-like spread of pathology.

Authors: Trevor Tyson; Jennifer A Steiner; Patrik Brundin
Journal: J Neurochem Date: 2016-02-10 Impact factor: 5.372

Review 4. Caenorhabditis elegans as an experimental tool for the study of complex neurological diseases: Parkinson's disease, Alzheimer's disease and autism spectrum disorder.

Authors: Fernando Calahorro; Manuel Ruiz-Rubio
Journal: Invert Neurosci Date: 2011-11-08

5. Proteasome inhibition-induced downregulation of Akt/GSK-3β pathway contributes to abnormality of tau in hippocampal slice.

Authors: Min Xie; Ruihong Shi; Ying Pan; Tao Zeng; Qicai Chen; Shaohui Wang; Xiaomei Liao
Journal: Mol Neurobiol Date: 2014-04-22 Impact factor: 5.590

Protein degradation, aggregation, and misfolding.

1. Redox control of 20S proteasome gating.

2. The ubiquitin E3 ligase parkin regulates the proapoptotic function of Bax.

Review 3. Sorting out release, uptake and processing of alpha-synuclein during prion-like spread of pathology.

Review 4. Caenorhabditis elegans as an experimental tool for the study of complex neurological diseases: Parkinson's disease, Alzheimer's disease and autism spectrum disorder.

5. Proteasome inhibition-induced downregulation of Akt/GSK-3β pathway contributes to abnormality of tau in hippocampal slice.

6. The Involvement of NR2B and tau Protein in MG132-Induced CREB Dephosphorylation.

Review 7. Role of various proteases in cardiac remodeling and progression of heart failure.

8. An angiogenic inhibitor, cyclic RGDfV, attenuates MPTP-induced dopamine neuron toxicity.

9. PGE2 EP1 receptor deletion attenuates 6-OHDA-induced Parkinsonism in mice: old switch, new target.

10. Age- and Hypertension-Associated Protein Aggregates in Mouse Heart Have Similar Proteomic Profiles.