Effect of blood flow on double inversion recovery vessel wall MRI of the peripheral arteries: quantitation with T2 mapping and comparison with flow-insensitive T2-prepared inversion recovery imaging.

Blood suppression in the lower extremities using flow-reliant methods such as double inversion recovery may be problematic due to slow blood flow. T(2) mapping using fast spin echo (FSE) acquisition was utilized to quantitate the effectiveness of double inversion recovery blood suppression in 13 subjects and showed that 25 +/- 12% of perceived vessel wall pixels in the popliteal arteries contained artifactual blood signal. To overcome this problem, a flow-insensitive T(2)-prepared inversion recovery sequence was implemented and optimal timing parameters were calculated for FSE acquisition. Black blood vessel wall imaging of the popliteal and femoral arteries was performed using two-dimensional T(2)-prepared inversion recovery-FSE in the same 13 subjects. Comparison with two-dimensional double inversion recovery-FSE showed that T(2)-prepared inversion recovery-FSE reduced wall-mimicking blood artifacts that inflated double inversion recovery-FSE vessel wall area measurements in the popliteal artery. (c) 2010 Wiley-Liss, Inc.