Jonathan P Shepherd1, Jerry L Lowder, Keisha A Jones, Kenneth J Smith. 1. Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Urogynecology and Reconstructive Pelvic Surgery, University of Pittsburgh Medical Center, Magee Women's Hospital, Pittsburgh, PA, USA. shepherdjp@upmc.edu
Abstract
INTRODUCTION AND HYPOTHESIS: The objective of this paper is to compare retropubic (RP) and transobturator (TO) midurethral slings using decision analysis techniques. METHODS: A decision analysis was constructed including efficacy and complication data. Probability of complication-free surgery and overall utility were analyzed using two models: ALL (all 42 trials) and RCT (seven randomized controlled trials with higher quality data, but missing data on some complications). RESULTS: Surgery was complication-free more frequently with TO approach with 83.7% vs. 55.7% (ALL) and 70.9% vs. 62.8% (RCT). One-year overall utility favored TO in the ALL model (0.943 vs. 0.895). Conversely, the RCT model favored RP (0.936 vs. 0.910). These differences were both less than published minimally important differences (MID) for utilities. Multiple one-way sensitivity analyses confirmed robustness of results. CONCLUSIONS: The difference between the two surgeries in both utility-based models was less than the MID. Therefore, the separate approaches are highly comparable with similar overall utility. Complications are more frequent with the retropubic approach.
INTRODUCTION AND HYPOTHESIS: The objective of this paper is to compare retropubic (RP) and transobturator (TO) midurethral slings using decision analysis techniques. METHODS: A decision analysis was constructed including efficacy and complication data. Probability of complication-free surgery and overall utility were analyzed using two models: ALL (all 42 trials) and RCT (seven randomized controlled trials with higher quality data, but missing data on some complications). RESULTS: Surgery was complication-free more frequently with TO approach with 83.7% vs. 55.7% (ALL) and 70.9% vs. 62.8% (RCT). One-year overall utility favored TO in the ALL model (0.943 vs. 0.895). Conversely, the RCT model favored RP (0.936 vs. 0.910). These differences were both less than published minimally important differences (MID) for utilities. Multiple one-way sensitivity analyses confirmed robustness of results. CONCLUSIONS: The difference between the two surgeries in both utility-based models was less than the MID. Therefore, the separate approaches are highly comparable with similar overall utility. Complications are more frequent with the retropubic approach.
Authors: Vivian W Sung; Mark D Schleinitz; Charles R Rardin; Renee M Ward; Deborah L Myers Journal: Am J Obstet Gynecol Date: 2007-07 Impact factor: 8.661
Authors: Mehdi Javanbakht; Eoin Moloney; Miriam Brazzelli; Sheila Wallace; Laura Ternent; Muhammad Imran Omar; Ash Monga; Lucky Saraswat; Phil Mackie; Frauke Becker; Mari Imamura; Jemma Hudson; Michal Shimonovich; Graeme MacLennan; Luke Vale; Dawn Craig Journal: BMJ Open Date: 2020-06-11 Impact factor: 2.692