| Literature DB >> 20186169 |
Nobuhiro Koyama1, Shigenobu Kojima, Kenichi Nonaka, Rokuro Masuma, Makoto Matsumoto, Satoshi Omura, Hiroshi Tomoda.
Abstract
Calpinactam, a new anti-mycobacterial agent, was isolated from the culture broth of a fungal strain Mortierella alpina FKI-4905 by solvent extraction, octadecyl silane column chromatography and preparative HPLC. Calpinactam was active only against Mycobacteria among various microorganisms, including Gram-positive and Gram-negative bacteria, fungi and yeasts. Calpinactam inhibited the growth of Mycobacterium smegmatis and Mycobacterium tuberculosis with MIC values of 0.78 and 12.5 microg ml(-1), respectively.Entities:
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Year: 2010 PMID： 20186169 DOI： 10.1038/ja.2010.14
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649