CONTENT: Patients with acromegaly have frequently colonic neoplasms; however, how acromegalic patients should be screened for colonic lesions is still unsettled. AIMS: To compare fecal occult blood testing (FOBT) and colonoscopy in the screening program of patients with acromegaly. DESIGN: Colonoscopy and FOBT were performed at the first diagnosis of acromegaly. SETTING: Tertiary University center. PATIENTS: Eighty-five consecutive patients with untreated active acromegaly submitted to colonoscopy and FOBT. RESULTS: FOBT, which was positive in 16 (18.8%) out of 85 patients, identified 2 patients with colonic adenocarcinoma and 2 with adenoma; the remaining 12 patients had no detectable colonic lesions. Colonoscopy revealed colonic lesions in 29 patients: 3 (3.5%) cancers, 11 (12.9%) adenomas, and 15 (17.6%) hyperplastic polyps. The remaining 56 acromegalic patients had no detectable lesions. A patient with cancer and 9 patients with adenoma were missed if screened only by FOBT. CONCLUSIONS: Colonoscopy is superior to FOBT in detecting colonic lesions at the first diagnosis of acromegaly.
CONTENT: Patients with acromegaly have frequently colonic neoplasms; however, how acromegalicpatients should be screened for colonic lesions is still unsettled. AIMS: To compare fecal occult blood testing (FOBT) and colonoscopy in the screening program of patients with acromegaly. DESIGN: Colonoscopy and FOBT were performed at the first diagnosis of acromegaly. SETTING: Tertiary University center. PATIENTS: Eighty-five consecutive patients with untreated active acromegaly submitted to colonoscopy and FOBT. RESULTS: FOBT, which was positive in 16 (18.8%) out of 85 patients, identified 2 patients with colonic adenocarcinoma and 2 with adenoma; the remaining 12 patients had no detectable colonic lesions. Colonoscopy revealed colonic lesions in 29 patients: 3 (3.5%) cancers, 11 (12.9%) adenomas, and 15 (17.6%) hyperplastic polyps. The remaining 56 acromegalicpatients had no detectable lesions. A patient with cancer and 9 patients with adenoma were missed if screened only by FOBT. CONCLUSIONS: Colonoscopy is superior to FOBT in detecting colonic lesions at the first diagnosis of acromegaly.
Authors: P J Jenkins; V Frajese; A M Jones; C Camacho-Hubner; D G Lowe; P D Fairclough; S L Chew; A B Grossman; J P Monson; G M Besser Journal: J Clin Endocrinol Metab Date: 2000-09 Impact factor: 5.958
Authors: S Grottoli; V Gasco; A Mainolfi; G Beccuti; G Corneli; G Aimaretti; C Dieguez; F Casanueva; E Ghigo Journal: J Endocrinol Invest Date: 2008-12 Impact factor: 4.256