| Literature DB >> 20185167 |
Eric W Holroyd1, Robert D Simari.
Abstract
Coagulation, innate immunity, angiogenesis, and lipid metabolism represent fundamental and interdependent biological systems. While tissue factor pathway inhibitor (TFPI) is the major physiological inhibitor of TF, its unique structure and endothelial expression allow multi-modal interactions with constituent molecules in each of these systems. We review emerging data describing roles for TFPI beyond simply opposing the action of TF, particularly with regard to the highly basic c-terminus of TFPI, and highlight potentially exciting new areas for future research. Copyright (c) 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20185167 PMCID： PMC2840704 DOI： 10.1016/j.thromres.2010.01.039
Source DB: PubMed Journal: Thromb Res ISSN： 0049-3848 Impact factor: 3.944