Literature DB >> 2018502

Synergistic effect of magnesium and calcium ions in the activation of phospholipase A2 of liver macrophages.

H Krause1, P Dieter, A Schulze-Specking, A Ballhorn, E Ferber, K Decker.   

Abstract

In cell-free extracts of rat liver macrophages (Kupffer cells) phospholipase A2 was found to be strongly activated at free Ca2+ concentrations from 100 nM to 1 microM in the presence of 4 mM free Mg2+. This is within the range of intracellular free Ca2+ reported for basal and various stimulated conditions, respectively. Ca2+ alone increased phospholipase A2 activity at high Ca2+ concentrations (1 mM) whereas Mg2+ alone had only little stimulatory effect. Calmodulin does not seem to participate in the regulation of phospholipase A2 although it relieved the inhibition of phospholipase A2 activity by calmodulin antagonists.

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Year:  1991        PMID： 2018502     DOI： 10.1016/0006-291x(91)91597-6

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  6 in total

Review 1.  Cell biology of liver endothelial and Kupffer cells.

Authors:  B Smedsrød; P J De Bleser; F Braet; P Lovisetti; K Vanderkerken; E Wisse; A Geerts
Journal:  Gut       Date:  1994-11       Impact factor: 23.059

2.  Zinc (Zn2+) binds to and stimulates the activity of group I but not group II phospholipase A2.

Authors:  M Lindahl; C Tagesson
Journal:  Inflammation       Date:  1996-12       Impact factor: 4.092

3.  Secretory phospholipase A2 inhibitors and calmodulin antagonists as inhibitors of cytosolic phospholipase A2.

Authors:  W C Hope; T Chen; D W Morgan
Journal:  Agents Actions       Date:  1993

4.  Late preventive effects of quinacrine on carbon tetrachloride induced liver necrosis.

Authors:  A González Padrón; E G de Toranzo; J A Castro
Journal:  Arch Toxicol       Date:  1993       Impact factor: 5.153

5.  Role of cytosolic phospholipase A2 in arachidonic acid release of rat-liver macrophages: regulation by Ca2+ and phosphorylation.

Authors:  P Ambs; M Baccarini; E Fitzke; P Dieter
Journal:  Biochem J       Date:  1995-10-01       Impact factor: 3.857

6.  Different roles of protein kinase C-beta and -delta in arachidonic acid cascade, superoxide formation and phosphoinositide hydrolysis.

Authors:  J Duyster; H Schwende; E Fitzke; H Hidaka; P Dieter
Journal:  Biochem J       Date:  1993-05-15       Impact factor: 3.857
  6 in total

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