Literature DB >> 20184890

Mammalian mitochondrial DNA replication intermediates are essentially duplex but contain extensive tracts of RNA/DNA hybrid.

Jaakko L O Pohjoismäki1, J Bradley Holmes, Stuart R Wood, Ming-Yao Yang, Takehiro Yasukawa, Aurelio Reyes, Laura J Bailey, Tricia J Cluett, Steffi Goffart, Smaranda Willcox, Rachel E Rigby, Andrew P Jackson, Johannes N Spelbrink, Jack D Griffith, Robert J Crouch, Howard T Jacobs, Ian J Holt.   

Abstract

We demonstrate, using transmission electron microscopy and immunopurification with an antibody specific for RNA/DNA hybrid, that intact mitochondrial DNA replication intermediates are essentially duplex throughout their length but contain extensive RNA tracts on one strand. However, the extent of preservation of RNA in such molecules is highly dependent on the preparative method used. These findings strongly support the strand-coupled model of mitochondrial DNA replication involving RNA incorporation throughout the lagging strand. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20184890      PMCID： PMC2857715          DOI： 10.1016/j.jmb.2010.02.029

Source DB:  PubMed          Journal:  J Mol Biol        ISSN： 0022-2836            Impact factor:   5.469


  37 in total

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Authors:  F Pileur; J J Toulme; C Cazenave
Journal:  Nucleic Acids Res       Date:  2000-09-15       Impact factor: 16.971

2.  Studies on the product binding sites of the Azotobacter vinelandii ribonucleic acid polymerase.

Authors:  S A Kumar; J S Krakow
Journal:  J Biol Chem       Date:  1975-04-25       Impact factor: 5.157

3.  R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells.

Authors:  Kefei Yu; Frederic Chedin; Chih-Lin Hsieh; Thomas E Wilson; Michael R Lieber
Journal:  Nat Immunol       Date:  2003-05       Impact factor: 25.606

4.  Structure of a T7 RNA polymerase elongation complex at 2.9 A resolution.

Authors:  Tahir H Tahirov; Dmitry Temiakov; Michael Anikin; Vsevolod Patlan; William T McAllister; Dmitry G Vassylyev; Shigeyuki Yokoyama
Journal:  Nature       Date:  2002-10-09       Impact factor: 49.962

5.  Multiple mechanisms for initiation of ColE1 DNA replication: DNA synthesis in the presence and absence of ribonuclease H.

Authors:  S Dasgupta; H Masukata; J Tomizawa
Journal:  Cell       Date:  1987-12-24       Impact factor: 41.582

6.  Replicating molecules of circular mitochondrial DNA.

Authors:  R H Kirschner; D R Wolstenholme; N J Gross
Journal:  Proc Natl Acad Sci U S A       Date:  1968-08       Impact factor: 11.205

7.  Nucleotide sequence of a region of human mitochondrial DNA containing the precisely identified origin of replication.

Authors:  S Crews; D Ojala; J Posakony; J Nishiguchi; G Attardi
Journal:  Nature       Date:  1979-01-18       Impact factor: 49.962

Review 8.  Replication of animal mitochondrial DNA.

Authors:  D A Clayton
Journal:  Cell       Date:  1982-04       Impact factor: 41.582

9.  Revisiting the mouse mitochondrial DNA sequence.

Authors:  María Pilar Bayona-Bafaluy; Rebeca Acín-Pérez; James C Mullikin; Jeong Soon Park; Raquel Moreno-Loshuertos; Peiqing Hu; Acisclo Pérez-Martos; Patricio Fernández-Silva; Yidong Bai; José Antonio Enríquez
Journal:  Nucleic Acids Res       Date:  2003-09-15       Impact factor: 16.971

10.  Native R-loops persist throughout the mouse mitochondrial DNA genome.

Authors:  Timothy A Brown; Ariana N Tkachuk; David A Clayton
Journal:  J Biol Chem       Date:  2008-11-05       Impact factor: 5.157
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  64 in total

Review 1.  Mitochondrial DNA replication and disease: insights from DNA polymerase γ mutations.

Authors:  Jeffrey D Stumpf; William C Copeland
Journal:  Cell Mol Life Sci       Date:  2010-10-08       Impact factor: 9.261

2.  An upstream open reading frame and the context of the two AUG codons affect the abundance of mitochondrial and nuclear RNase H1.

Authors:  Yutaka Suzuki; J Bradley Holmes; Susana M Cerritelli; Kiran Sakhuja; Michal Minczuk; Ian J Holt; Robert J Crouch
Journal:  Mol Cell Biol       Date:  2010-09-07       Impact factor: 4.272

3.  Overexpression of MTERFD1 or MTERFD3 impairs the completion of mitochondrial DNA replication.

Authors:  Anne K Hyvärinen; Jaakko L O Pohjoismäki; Ian J Holt; Howard T Jacobs
Journal:  Mol Biol Rep       Date:  2010-06-25       Impact factor: 2.316

4.  Replication intermediates of the linear mitochondrial DNA of Candida parapsilosis suggest a common recombination based mechanism for yeast mitochondria.

Authors:  Joachim M Gerhold; Tiina Sedman; Katarina Visacka; Judita Slezakova; Lubomir Tomaska; Jozef Nosek; Juhan Sedman
Journal:  J Biol Chem       Date:  2014-06-20       Impact factor: 5.157

5.  Import of desired nucleic acid sequences using addressing motif of mitochondrial ribosomal 5S-rRNA for fluorescent in vivo hybridization of mitochondrial DNA and RNA.

Authors:  Jaroslav Zelenka; Lukáš Alán; Martin Jabůrek; Petr Ježek
Journal:  J Bioenerg Biomembr       Date:  2014-02-23       Impact factor: 2.945

6.  NRDE-2, the human homolog of fission yeast Nrl1, prevents DNA damage accumulation in human cells.

Authors:  Patricia Richard; Koichi Ogami; Yaqiong Chen; Shuang Feng; James J Moresco; John R Yates; James L Manley
Journal:  RNA Biol       Date:  2018-08-02       Impact factor: 4.652

7.  Novel Lines of Evidence for the Asymmetric Strand Displacement Model of Mitochondrial DNA Replication.

Authors:  Chih-Lin Hsieh
Journal:  Mol Cell Biol       Date:  2019-01-03       Impact factor: 4.272

Review 8.  Animal Mitochondrial DNA Replication.

Authors:  G L Ciesielski; M T Oliveira; L S Kaguni
Journal:  Enzymes       Date:  2016-05-09

9.  Pathological ribonuclease H1 causes R-loop depletion and aberrant DNA segregation in mitochondria.

Authors:  Gokhan Akman; Radha Desai; Laura J Bailey; Takehiro Yasukawa; Ilaria Dalla Rosa; Romina Durigon; J Bradley Holmes; Chloe F Moss; Mara Mennuni; Henry Houlden; Robert J Crouch; Michael G Hanna; Robert D S Pitceathly; Antonella Spinazzola; Ian J Holt
Journal:  Proc Natl Acad Sci U S A       Date:  2016-07-08       Impact factor: 11.205

10.  Developmental and pathological changes in the human cardiac muscle mitochondrial DNA organization, replication and copy number.

Authors:  Jaakko L O Pohjoismäki; Steffi Goffart; Robert W Taylor; Douglas M Turnbull; Anu Suomalainen; Howard T Jacobs; Pekka J Karhunen
Journal:  PLoS One       Date:  2010-05-03       Impact factor: 3.240
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