| Literature DB >> 20184864 |
Seung Hee Baek1, Young-Chang Kwon, Hyangkyu Lee, Kwang-Min Choe.
Abstract
A wound induces cell polarization, in which myosin II is localized at the rear end of individual cells in a migrating epithelial sheet of the Drosophila larval epidermis. Here, we use myosin localization to demonstrate that Rac1, Cdc42, and Rho1 are each required for cell polarization and directional sensing of the wound. The three GTPases are also required for actin cable formation at the wound leading edge. Rac1, Cdc42, and Rho1 act upstream of c-Jun N-terminal kinase (JNK) to organize actin assembly. These results highlight the similarities between the molecular mechanism of Drosophila wound healing and those of Drosophila embryonic dorsal closure and the chemotactic response of Dictyostelium and leukocytes. Copyright 2010 Elsevier Inc. All rights reserved.Entities:
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Year: 2010 PMID： 20184864 DOI： 10.1016/j.bbrc.2010.02.124
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575