Literature DB >> 20184701

Polyploidy in chronic lymphocytic leukemia with p53 deletion detected by fish: a case report.

Maha Eid1, Hesham Kayed, Hala T El-Bassyouni.   

Abstract

We report a case of chronic lymphocytic leukemia with a characteristic cytogenetics finding detected by fluorescent in situ hybridization. This case has deletion in p53 gene in 50% of interphase nuclei studied in the peripheral blood and polyploidy in 30% of cells. To our knowledge polyploidy is not commonly reported with chronic lymphocytic leukemia patients.

Entities:  

Year:  2009        PMID： 20184701      PMCID： PMC2827117          DOI： 10.4076/1757-1626-2-8872

Source DB:  PubMed          Journal:  Cases J        ISSN： 1757-1626


  8 in total

1.  Rituximab dose-escalation trial in chronic lymphocytic leukemia.

Authors:  S M O'Brien; H Kantarjian; D A Thomas; F J Giles; E J Freireich; J Cortes; S Lerner; M J Keating
Journal:  J Clin Oncol       Date:  2001-04-15       Impact factor: 44.544

2.  The value of fluorescence in situ hybridization in the diagnosis and prognosis of chronic lymphocytic leukemia.

Authors:  Armand B Glassman; Kimberly J Hayes
Journal:  Cancer Genet Cytogenet       Date:  2005-04-01

Review 3.  Guilt by association? p53 and the development of aneuploidy in cancer.

Authors:  Anette Duensing; Stefan Duensing
Journal:  Biochem Biophys Res Commun       Date:  2005-06-10       Impact factor: 3.575

4.  Genomic aberrations and survival in chronic lymphocytic leukemia.

Authors:  H Döhner; S Stilgenbauer; A Benner; E Leupolt; A Kröber; L Bullinger; K Döhner; M Bentz; P Lichter
Journal:  N Engl J Med       Date:  2000-12-28       Impact factor: 91.245

5.  Prognostic significance of ATM and TP53 deletions in Chinese patients with chronic lymphocytic leukemia.

Authors:  Wei Xu; Jian-Yong Li; Yu-Jie Wu; Hui Yu; Qiu-Dan Shen; Li Li; Lei Fan; Hong-Xia Qiu
Journal:  Leuk Res       Date:  2007-11-26       Impact factor: 3.156

6.  Chromosome anomalies detected by interphase fluorescence in situ hybridization: correlation with significant biological features of B-cell chronic lymphocytic leukaemia.

Authors:  Gordon W Dewald; Stephanie R Brockman; Sarah F Paternoster; Nancy D Bone; Judith R O'Fallon; Cristine Allmer; Charles D James; Diane F Jelinek; Renee C Tschumper; Curtis A Hanson; Rajiv K Pruthi; Thomas E Witzig; Timothy G Call; Neil E Kay
Journal:  Br J Haematol       Date:  2003-04       Impact factor: 6.998

Review 7.  The impact of p53 and p73 on aneuploidy and cancer.

Authors:  Richard Tomasini; Tak W Mak; Gerry Melino
Journal:  Trends Cell Biol       Date:  2008-04-10       Impact factor: 20.808

8.  The detection of TP53 mutations in chronic lymphocytic leukemia independently predicts rapid disease progression and is highly correlated with a complex aberrant karyotype.

Authors:  F Dicker; H Herholz; S Schnittger; A Nakao; N Patten; L Wu; W Kern; T Haferlach; C Haferlach
Journal:  Leukemia       Date:  2008-10-09       Impact factor: 11.528
  8 in total

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