OBJECTIVE: To examine the association of serum vitamin D level with metabolic syndrome (MetS) and hypertension (HTN) in middle-aged Korean subjects. DESIGN AND SUBJECTS: We conducted a population-based, cross-sectional survey of 1330 participants aged over 40 years (median age 65.8 years) in Chungju, Korea, in 2007. The 324 subjects, who were normotensive in 2003 and who attended a follow-up visit 4 years later, were included in an analysis of the association of serum vitamin D level with the risk of HTN. MEASUREMENTS: Serum 25-hydroxy-vitamin D [25(OH)D] and PTH were measured in a central laboratory, using chemiluminescence assays. RESULTS: The overall prevalence of the MetS in participants of this study was 45.3%. After adjusting for various covariates, subjects in the highest quintile group (61.4-116.8 nmol/l) compared with the lowest quintile group (10.0-29.7 nmol/l) of 25(OH)D had an odds ratio (OR) for having MetS of 0.35 (95% confidence intervals, CI, 0.22-0.56; P for trend <0.001). The median level of 25(OH)D was 46.8 nmol/l among 324 subjects who were normotensive in 2003. After multiple adjustment, the OR was substantially higher for new HTN (OR 2.74; 95% CI 1.40-5.34) in subjects with serum 25(OH)D levels below the median value compared with those above median. The inverse associations of vitamin D and MetS/HTN were unchanged after adjustment for PTH and serum calcium levels. There was no association between PTH and MetS. CONCLUSIONS: We found a strong inverse association of 25(OH)D levels with MetS and HTN in this middle-aged Korean population. Having vitamin D deficiency was associated with an increased risk of having MetS and HTN in this demographic group.
OBJECTIVE: To examine the association of serum vitamin D level with metabolic syndrome (MetS) and hypertension (HTN) in middle-aged Korean subjects. DESIGN AND SUBJECTS: We conducted a population-based, cross-sectional survey of 1330 participants aged over 40 years (median age 65.8 years) in Chungju, Korea, in 2007. The 324 subjects, who were normotensive in 2003 and who attended a follow-up visit 4 years later, were included in an analysis of the association of serum vitamin D level with the risk of HTN. MEASUREMENTS: Serum 25-hydroxy-vitamin D [25(OH)D] and PTH were measured in a central laboratory, using chemiluminescence assays. RESULTS: The overall prevalence of the MetS in participants of this study was 45.3%. After adjusting for various covariates, subjects in the highest quintile group (61.4-116.8 nmol/l) compared with the lowest quintile group (10.0-29.7 nmol/l) of 25(OH)D had an odds ratio (OR) for having MetS of 0.35 (95% confidence intervals, CI, 0.22-0.56; P for trend <0.001). The median level of 25(OH)D was 46.8 nmol/l among 324 subjects who were normotensive in 2003. After multiple adjustment, the OR was substantially higher for new HTN (OR 2.74; 95% CI 1.40-5.34) in subjects with serum 25(OH)D levels below the median value compared with those above median. The inverse associations of vitamin D and MetS/HTN were unchanged after adjustment for PTH and serum calcium levels. There was no association between PTH and MetS. CONCLUSIONS: We found a strong inverse association of 25(OH)D levels with MetS and HTN in this middle-aged Korean population. Having vitamin D deficiency was associated with an increased risk of having MetS and HTN in this demographic group.
Authors: Sara A Chacko; Yiqing Song; JoAnn E Manson; Linda Van Horn; Charles Eaton; Lisa W Martin; Anne McTiernan; J David Curb; Judith Wylie-Rosett; Lawrence S Phillips; Raymond A Plodkowski; Simin Liu Journal: Am J Clin Nutr Date: 2011-05-25 Impact factor: 7.045
Authors: J Mitri; J Nelson; R Ruthazer; C Garganta; D M Nathan; F B Hu; B Dawson-Hughes; A G Pittas Journal: Eur J Clin Nutr Date: 2014-01-22 Impact factor: 4.016
Authors: Jennifer W Bea; Peter W Jurutka; Elizabeth A Hibler; Peter Lance; Maria E Martínez; Denise J Roe; Christine L Sardo Molmenti; Patricia A Thompson; Elizabeth T Jacobs Journal: Metabolism Date: 2014-11-29 Impact factor: 8.694