Literature DB >> 2018432

Exposure to acidic pH causes irreversible conformational changes in the measles virus hemagglutinin.

H Sheshberadaran1.   

Abstract

Temporary exposure to acidic pH caused the hemagglutinin (H) protein of measles virus to lose hemagglutinating activity and undergo antigenic changes. The antigenic changes, detected as alterations in reactivity of several anti-H protein monoclonal antibodies, were characterised by ELISA and radioimmune precipitation assay. The possible biological instances of such conformational changes within the paramyxovirus H protein are discussed.

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Year:  1991        PMID： 2018432     DOI： 10.1007/bf01310774

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  8 in total

1.  Membrane penetration of Sendai virus glycoproteins during the early stages of fusion with liposomes as determined by hydrophobic photoaffinity labeling.

Authors:  S L Novick; D Hoekstra
Journal:  Proc Natl Acad Sci U S A       Date:  1988-10       Impact factor: 11.205

2.  Characterization of epitopes on the measles virus hemagglutinin.

Authors:  H Sheshberadaran; E Norrby
Journal:  Virology       Date:  1986-07-15       Impact factor: 3.616

3.  Monoclonal antibodies against five structural components of measles virus. I. Characterization of antigenic determinants on nine strains of measles virus.

Authors:  H Sheshberadaran; S N Chen; E Norrby
Journal:  Virology       Date:  1983-07-30       Impact factor: 3.616

4.  The uncoating of paramyxoviruses may not require a low pH mediated step.

Authors:  Y Nagai; M Hamaguchi; T Toyoda; T Yoshida
Journal:  Virology       Date:  1983-10-15       Impact factor: 3.616

5.  Parameters affecting fusion between Sendai virus and liposomes. Role of viral proteins, liposome composition, and pH.

Authors:  K Klappe; J Wilschut; S Nir; D Hoekstra
Journal:  Biochemistry       Date:  1986-12-16       Impact factor: 3.162

6.  Identification of measles virus-specific hemolysis-inihibiting antibodies separate from hemagglutination-inhibiting antibodies.

Authors:  E Norrby; Y Gollmar
Journal:  Infect Immun       Date:  1975-02       Impact factor: 3.441

7.  Purification, morphology and antigenic characterization of measles virus envelope components.

Authors:  T M Varsanyi; G Utter; E Norrby
Journal:  J Gen Virol       Date:  1984-02       Impact factor: 3.891

8.  Intracellular maturation and transport of the SV5 type II glycoprotein hemagglutinin-neuraminidase: specific and transient association with GRP78-BiP in the endoplasmic reticulum and extensive internalization from the cell surface.

Authors:  D T Ng; R E Randall; R A Lamb
Journal:  J Cell Biol       Date:  1989-12       Impact factor: 10.539
  8 in total

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