Literature DB >> 20183606

Carbocyclic thymidine analogues for use as potential therapeutic agents.

Katherine L Seley-Radtke1, Naresh K Sunkara.   

Abstract

The discovery of azidothymidine's (AZT) activity against human immunodeficiency virus (HIV) provided strong rationale for the design of additional thymidine analogues. One drawback of many nucleoside analogues is the toxicity that often arises due to phosphorylation by cellular kinases. In order to overcome this problem, a number of truncated nucleosides lacking the 4'-hydroxymethyl group have been synthesized. In that regard, the synthesis and preliminary biological results for two truncated carbocyclic thymidine analogues are presented herein.

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Year:  2009        PMID： 20183606      PMCID： PMC3701155          DOI： 10.1080/15257770903091920

Source DB:  PubMed          Journal:  Nucleosides Nucleotides Nucleic Acids        ISSN： 1525-7770            Impact factor:   1.381


  28 in total

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Journal:  J Med Chem       Date:  1988-01       Impact factor: 7.446

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Journal:  J Med Chem       Date:  1990-05       Impact factor: 7.446

5.  Phosphonoformate and phosphonoacetate derivatives of 5-substituted 2'-deoxyuridines: synthesis and antiviral activity.

Authors:  H Griengl; W Hayden; G Penn; E De Clercq; B Rosenwirth
Journal:  J Med Chem       Date:  1988-09       Impact factor: 7.446

6.  Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine.

Authors:  J Balzarini; H Baumgartner; M Bodenteich; E De Clercq; H Griengl
Journal:  J Med Chem       Date:  1989-08       Impact factor: 7.446

7.  Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties.

Authors:  V E Marquez; M I Lim; S P Treanor; J Plowman; M A Priest; A Markovac; M S Khan; B Kaskar; J S Driscoll
Journal:  J Med Chem       Date:  1988-09       Impact factor: 7.446

8.  Effects of 9-(trans-2',trans-3'-dihydroxycyclopent-4'-enyl)-adenine and -3-deazaadenine on the metabolism of S-adenosylhomocysteine in mouse L929 cells.

Authors:  M Hasobe; J G Mckee; D R Borcherding; B T Keller; R T Borchardt
Journal:  Mol Pharmacol       Date:  1988-06       Impact factor: 4.436

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Authors:  E De Clercq; R Bernaerts; Y F Shealy; J A Montgomery
Journal:  Biochem Pharmacol       Date:  1990-01-15       Impact factor: 5.858

10.  Broad-spectrum antiviral and cytocidal activity of cyclopentenylcytosine, a carbocyclic nucleoside targeted at CTP synthetase.

Authors:  E De Clercq; J Murase; V E Marquez
Journal:  Biochem Pharmacol       Date:  1991-06-15       Impact factor: 5.858
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