Literature DB >> 20182700

[Cell therapy in bone-healing disorders].

M Jäger1, P Hernigou, C Zilkens, M Herten, J Fischer, R Krauspe.   

Abstract

In addition to stabilizing osteosynthesis and autologous bone transplantation, so-called orthobiologics are playing an increasing role in the treatment of bone-healing disorders. Besides the application of different growth factors, new data in the literature suggest that cell therapeutic agents promote local bone regeneration. Due to ethical and biological considerations, clinical application of progenitor cells for the musculoskeletal system is limited to autologous postpartum stem cells. Here in particular, cell therapy with autologous progenitor cells in one surgical session has delivered first promising results. Based on a review of the literature and on our own experience with 75 patients, this article reviews the rationale and characteristics of the clinical application of cell therapy for the treatment of bony substance defects. Most clinical trials report successful bone regeneration after the application of mixed cell populations from bone marrow.

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Year:  2010        PMID： 20182700     DOI： 10.1007/s00132-009-1583-7

Source DB:  PubMed          Journal:  Orthopade        ISSN： 0085-4530            Impact factor:   1.087


  73 in total

1.  Percutaneous autologous bone-marrow grafting for nonunions. Influence of the number and concentration of progenitor cells.

Authors:  Ph Hernigou; A Poignard; F Beaujean; H Rouard
Journal:  J Bone Joint Surg Am       Date:  2005-07       Impact factor: 5.284

2.  Umbilical cord blood stem cells: induction of differentiation into mesenchymal lineages by cell-cell contacts with various mesenchymal cells.

Authors:  Jung Park; Viviane Setter; Viktor Wixler; Holm Schneider
Journal:  Tissue Eng Part A       Date:  2009-02       Impact factor: 3.845

3.  Defining stem and progenitor cells within adipose tissue.

Authors:  Guiting Lin; Maurice Garcia; Hongxiu Ning; Lia Banie; Ying-Lu Guo; Tom F Lue; Ching-Shwun Lin
Journal:  Stem Cells Dev       Date:  2008-12       Impact factor: 3.272

4.  Gene expression patterns related to osteogenic differentiation of bone marrow-derived mesenchymal stem cells during ex vivo expansion.

Authors:  Donatella Granchi; Gorka Ochoa; Elisa Leonardi; Valentina Devescovi; Serena Rubina Baglìo; Lourdes Osaba; Nicola Baldini; Gabriela Ciapetti
Journal:  Tissue Eng Part C Methods       Date:  2010-06       Impact factor: 3.056

5.  Bone repair by transplantation of hTERT-immortalized human mesenchymal stem cells in mice.

Authors:  Hiroyuki Nakahara; Haruo Misawa; Takahiro Hayashi; Eisaku Kondo; Takeshi Yuasa; Yasuhiro Kubota; Masayuki Seita; Hironobu Kawamoto; Wael A R A Hassan; Reham A R A Hassan; Shahid M Javed; Masato Tanaka; Hirosuke Endo; Hirofumi Noguchi; Shinichi Matsumoto; Katsuyoshi Takata; Yuichi Tashiro; Shuhei Nakaji; Toshifumi Ozaki; Naoya Kobayashi
Journal:  Transplantation       Date:  2009-08-15       Impact factor: 4.939

6.  Age- and gender-related changes in the cellularity of human bone marrow and the prevalence of osteoblastic progenitors.

Authors:  G F Muschler; H Nitto; C A Boehm; K A Easley
Journal:  J Orthop Res       Date:  2001-01       Impact factor: 3.494

7.  Determination of the fate and contribution of ex vivo expanded human bone marrow stem and progenitor cells for bone formation by 2.3ColGFP.

Authors:  Dezhong Yin; Zhuo Wang; Qinghong Gao; Renuka Sundaresan; Chris Parrish; Qingfen Yang; Paul H Krebsbach; Alexander C Lichtler; David W Rowe; Janet Hock; Peng Liu
Journal:  Mol Ther       Date:  2009-07-14       Impact factor: 11.454

8.  Severe pulmonary hypertension: a frequent complication of stem cell transplantation for malignant infantile osteopetrosis.

Authors:  C G Steward; I Pellier; A Mahajan; M T Ashworth; A G Stuart; A Fasth; D Lang; A Fischer; W Friedrich; A S Schulz
Journal:  Br J Haematol       Date:  2004-01       Impact factor: 6.998

Review 9.  The biology of platelet-rich plasma and its application in trauma and orthopaedic surgery: a review of the literature.

Authors:  J Alsousou; M Thompson; P Hulley; A Noble; K Willett
Journal:  J Bone Joint Surg Br       Date:  2009-08

Review 10.  Mesenchymal stem cells for bone repair and metabolic bone diseases.

Authors:  Anita H Undale; Jennifer J Westendorf; Michael J Yaszemski; Sundeep Khosla
Journal:  Mayo Clin Proc       Date:  2009-10       Impact factor: 7.616
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  7 in total

1.  Arthroscopically assisted retrograde drilling of the humeral head with a guiding device.

Authors:  Jörn Kircher; Thilo Patzer; Christoph Ziskoven; Bernd Bittersohl; Achim Hedtmann; Rüdiger Krauspe
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2013-12-03       Impact factor: 4.342

2.  Magnetic resonance imaging of hip joint cartilage and labrum.

Authors:  Christoph Zilkens; Falk Miese; Marcus Jäger; Bernd Bittersohl; Rüdiger Krauspe
Journal:  Orthop Rev (Pavia)       Date:  2011-06-29

3.  The composite of bone marrow concentrate and PRP as an alternative to autologous bone grafting.

Authors:  Mohssen Hakimi; Jan-Peter Grassmann; Marcel Betsch; Johannes Schneppendahl; Sebastian Gehrmann; Ahmad-Reza Hakimi; Patric Kröpil; Martin Sager; Monika Herten; Michael Wild; Joachim Windolf; Pascal Jungbluth
Journal:  PLoS One       Date:  2014-06-20       Impact factor: 3.240

4.  Clinical trial and in-vitro study comparing the efficacy of treating bony lesions with allografts versus synthetic or highly-processed xenogeneic bone grafts.

Authors:  Eva Johanna Kubosch; Anke Bernstein; Laura Wolf; Tobias Fretwurst; Katja Nelson; Hagen Schmal
Journal:  BMC Musculoskelet Disord       Date:  2016-02-13       Impact factor: 2.362

5.  Effectiveness of a single intra-articular bone marrow aspirate concentrate (BMAC) injection in patients with grade 3 and 4 knee osteoarthritis.

Authors:  George S Themistocleous; George D Chloros; Ioannis M Kyrantzoulis; Ioannis A Georgokostas; Marios S Themistocleous; Panayiotis J Papagelopoulos; Olga D Savvidou
Journal:  Heliyon       Date:  2018-10-18

6.  Assessment of Methods for Rapid Intraoperative Concentration and Selection of Marrow-Derived Connective Tissue Progenitors for Bone Regeneration Using the Canine Femoral Multidefect Model.

Authors:  Viviane Luangphakdy; Cynthia Boehm; Hui Pan; James Herrick; Phil Zaveri; George F Muschler
Journal:  Tissue Eng Part A       Date:  2016-01       Impact factor: 3.845

7.  Surgical vacuum filter-derived stromal cells are superior in proliferation to human bone marrow aspirate.

Authors:  Katharina Henze; Monika Herten; Marcel Haversath; André Busch; Sven Brandau; Alexander Hackel; Stefanie B Flohé; Marcus Jäger
Journal:  Stem Cell Res Ther       Date:  2019-11-21       Impact factor: 6.832
  7 in total

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