OBJECTIVE: Identify echocardiographic parameters at <or=4 day postnatal that predict the subsequent need for closure of a clinically significant patent ductus arteriosus (sPDA) in extremely-low-birth-weight neonates (ELBW). STUDY DESIGN: Serial echocardiograms obtained in 115 ELBW at <or=10 day postnatal were examined to estimate PDA size using the PDA:left pulmonary artery (LPA) diameter ratio: >or=1 indicated a large PDA, <1 but >or=0.5 moderate, and <0.5 small. Sensitivity, specificity, and positive predictive values (PPV) were determined for ELBW <27 weeks and >or=27 weeks gestational age. RESULT: Neonates with moderate to large PDA at <or=4 day had 15-times greater likelihood of requiring treatment for sPDA than those with a small PDA (95% confidence interval (CI): 5.6-41). Sensitivity, specificity and PPV of the PDA:LPA at <27 weeks was 80, 86 and 92%, respectively. CONCLUSION: A moderate to large PDA determined from the PDA:LPA ratio at <or=4 day postnatal identifies neonates <27 week gestation who subsequently require closure of a PDA.
OBJECTIVE: Identify echocardiographic parameters at <or=4 day postnatal that predict the subsequent need for closure of a clinically significant patent ductus arteriosus (sPDA) in extremely-low-birth-weight neonates (ELBW). STUDY DESIGN: Serial echocardiograms obtained in 115 ELBW at <or=10 day postnatal were examined to estimate PDA size using the PDA:left pulmonary artery (LPA) diameter ratio: >or=1 indicated a large PDA, <1 but >or=0.5 moderate, and <0.5 small. Sensitivity, specificity, and positive predictive values (PPV) were determined for ELBW <27 weeks and >or=27 weeks gestational age. RESULT: Neonates with moderate to large PDA at <or=4 day had 15-times greater likelihood of requiring treatment for sPDA than those with a small PDA (95% confidence interval (CI): 5.6-41). Sensitivity, specificity and PPV of the PDA:LPA at <27 weeks was 80, 86 and 92%, respectively. CONCLUSION: A moderate to large PDA determined from the PDA:LPA ratio at <or=4 day postnatal identifies neonates <27 week gestation who subsequently require closure of a PDA.
Authors: Philip T Levy; Brittney Dioneda; Mark R Holland; Timothy J Sekarski; Caroline K Lee; Amit Mathur; W Todd Cade; Alison G Cahill; Aaron Hamvas; Gautam K Singh Journal: J Am Soc Echocardiogr Date: 2015-03-07 Impact factor: 5.251
Authors: Swati Choudhry; Amber Salter; Tyler W Cunningham; Philip T Levy; Hoang H Nguyen; Michael Wallendorf; Gautam K Singh; Mark C Johnson Journal: J Am Soc Echocardiogr Date: 2017-06-07 Impact factor: 5.251
Authors: Philip T Levy; Afif El-Khuffash; Meghna D Patel; Colm R Breatnach; Adam T James; Aura A Sanchez; Cristina Abuchabe; Sarah R Rogal; Mark R Holland; Patrick J McNamara; Amish Jain; Orla Franklin; Luc Mertens; Aaron Hamvas; Gautam K Singh Journal: J Am Soc Echocardiogr Date: 2017-04-19 Impact factor: 5.251
Authors: Dawn M Weiss; Jeffrey R Kaiser; Christopher Swearingen; Sadia Malik; Ritu Sachdeva Journal: Am J Perinatol Date: 2015-06-09 Impact factor: 1.862