Literature DB >> 2018075

Multipoint linkage analysis of DXS369 and DXS304 in fragile X families.

B A van Oost1, A Smits, J C Dreesen, D Smeets, L Perdon, C A van Bennekom, N Dahl, E Bakker, B A Oostra.   

Abstract

Diagnosis of carriers of the fragile-X mental retardation gene is hampered by the paucity of tightly linked DNA markers. Recently, 2 new DNA markers RN1 (DXS369) and U6.2 (DXS304) have become available. Both markers are tightly linked to the fragile-X locus, but their location relative to the fragile site was not known with certainty. We have tested these new markers in a multipoint linkage analysis of 26 fragile-X families typed for DXS105 as a proximal marker and DXS52 as a distal marker. Our results establish the order DXS105-DXS369-fra(X)-DXS304-DXS52, which is in agreement with physical mapping results.

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Year:  1991        PMID： 2018075     DOI： 10.1002/ajmg.1320380232

Source DB:  PubMed          Journal:  Am J Med Genet        ISSN： 0148-7299


  4 in total

1.  Linkage analysis in X-linked adrenoleukodystrophy and application in post- and prenatal diagnosis.

Authors:  B A van Oost; P M van Zandvoort; W Tünte; H G Brunner; A J Hoogeboom; P D Maaswinkel-Mooy; J Bakkeren; B Hamel; H H Ropers
Journal:  Hum Genet       Date:  1991-02       Impact factor: 4.132

2.  DXS539, a polymorphic DNA marker proximal of the fragile-X gene.

Authors:  J C Dreesen; J A van den Hurk; A P Smits; A M van den Ouweland; P W Markslag; B A van Oost
Journal:  Hum Genet       Date:  1993-03       Impact factor: 4.132

3.  Linkage analysis of keratosis follicularis spinulosa decalvans, and regional assignment to human chromosome Xp21.2-p22.2.

Authors:  J C Oosterwijk; M Nelen; P M van Zandvoort; L D van Osch; A P Oranje; D Wittebol-Post; B A van Oost
Journal:  Am J Hum Genet       Date:  1992-04       Impact factor: 11.025

4.  X-linked borderline mental retardation with prominent behavioral disturbance: phenotype, genetic localization, and evidence for disturbed monoamine metabolism.

Authors:  H G Brunner; M R Nelen; P van Zandvoort; N G Abeling; A H van Gennip; E C Wolters; M A Kuiper; H H Ropers; B A van Oost
Journal:  Am J Hum Genet       Date:  1993-06       Impact factor: 11.025
  4 in total

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