Literature DB >> 20180530

How an enzyme might accelerate an intramolecular Diels-Alder reaction: theozymes for the formation of salvileucalin B.

Dean J Tantillo1.   

Abstract

Quantum chemical calculations reveal how functional group arrays present in known enzyme active sites could accelerate an intramolecular Diels-Alder reaction proposed to occur during the biosynthesis of a complex terpenoid natural product.

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Year:  2010        PMID: 20180530     DOI: 10.1021/ol9028435

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  2 in total

1.  Computational study of a model system of enzyme-mediated [4+2] cycloaddition reaction.

Authors:  Evgeniy G Gordeev; Valentine P Ananikov
Journal:  PLoS One       Date:  2015-04-08       Impact factor: 3.240

Review 2.  Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently.

Authors:  Andrew Currin; Neil Swainston; Philip J Day; Douglas B Kell
Journal:  Chem Soc Rev       Date:  2015-03-07       Impact factor: 54.564

  2 in total

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