Literature DB >> 20180522

Schinalactone A, a new cytotoxic triterpenoid from Schisandra sphenanthera.

Fei He1, Jian-Xin Pu, Sheng-Xiong Huang, Yuan-Yuan Wang, Wei-Lie Xiao, Li-Mei Li, Jing-Ping Liu, Hai-Bo Zhang, Yan Li, Han-Dong Sun.   

Abstract

A new cytotoxic triterpenoid, schinalactone A (1), together with two new biogenetically related compounds, schinalactones B (2) and C (3), has been isolated from the roots and stems of Schisandra sphenanthera.Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 1 and 2 showed significant cytotoxicity against PANC-1 cell lines with IC(50) values of 5.9 and 4.1 microM, respectively. A plausible biosynthetic pathway of 1 was also postulated.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20180522     DOI： 10.1021/ol902974j

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  8 in total

1.  Anti-RAFLS Triterpenoids and Hepatoprotective Lignans From the Leaves of Tujia Ethnomedicine Kadsura heteroclita (Xuetong).

Authors:  Mengyun Wang; Sai Jiang; Nusrat Hussain; Salman Zafar; Qingling Xie; Feibing Huang; Linxi Mao; Bin Li; Yuqing Jian; Wei Wang
Journal:  Front Chem       Date:  2022-05-10       Impact factor: 5.545

2.  Isolation, Structural Elucidation of Three New Triterpenoids from the Stems and Leaves of Schisandra chinensis (Turcz) Baill.

Authors:  Feng Qiu; Han Liu; Huan Duan; Pian Chen; Shao-Juan Lu; Guang-Zhong Yang; Xin-Xiang Lei
Journal:  Molecules       Date:  2018-07-04       Impact factor: 4.411

Review 3.  Harvest, After 50 Years of Sowing.

Authors:  Pema-Tenzin Puno
Journal:  Nat Prod Bioprospect       Date:  2018-07-19

4.  Synthesis of Ergosterol Peroxide Conjugates as Mitochondria Targeting Probes for Enhanced Anticancer Activity.

Authors:  Ming Bu; Hongling Li; Haijun Wang; Jing Wang; Yu Lin; Yukun Ma
Journal:  Molecules       Date:  2019-09-11       Impact factor: 4.411

Review 5.  Antiprotozoal and Antitumor Activity of Natural Polycyclic Endoperoxides: Origin, Structures and Biological Activity.

Authors:  Valery M Dembitsky; Ekaterina Ermolenko; Nick Savidov; Tatyana A Gloriozova; Vladimir V Poroikov
Journal:  Molecules       Date:  2021-01-28       Impact factor: 4.411

6.  Anti-asthmatic fraction screening and mechanisms prediction of Schisandrae Sphenantherae Fructus based on a combined approach.

Authors:  Fan Li; Bin Li; Jiushi Liu; Xueping Wei; Tingyan Qiang; Xinlu Mu; Yumeng Wang; Yaodong Qi; Bengang Zhang; Haitao Liu; Peigen Xiao
Journal:  Front Pharmacol       Date:  2022-09-12       Impact factor: 5.988

7.  Two New 3,4;9,10-seco-Cycloartane Type Triterpenoids from Illicium difengpi and Their Anti-Inflammatory Activities.

Authors:  Chuntong Li; Fengmin Xi; Junling Mi; Zhijun Wu; Wansheng Chen
Journal:  Evid Based Complement Alternat Med       Date:  2013-05-15       Impact factor: 2.629

8.  Chinese Medicine for Psoriasis Vulgaris Based on Syndrome Pattern: A Network Pharmacological Study.

Authors:  Dongmei Wang; Chuanjian Lu; Jingjie Yu; Miaomiao Zhang; Wei Zhu; Jiangyong Gu
Journal:  Evid Based Complement Alternat Med       Date:  2020-04-28       Impact factor: 2.629
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.