Literature DB >> 20180082

Gastrointestinal stromal tumor with two genetic abnormalities on different alleles: report of a case.

Yasushi Ichikawa1, Yohei Miyagi, Shoichi Fujii, Mitsuyoshi Ota, Shigeru Yamagishi, Shingo Hasegawa, Shuuji Saito, Hideyuki Ike, Shigeo Ohki, Akira Nakano, Naomi Matsumura, Takashi Ishikawa, Chikara Kunizaki, Hiroshi Shimada.   

Abstract

We report a case of a gastrointestinal stromal tumor (GIST) with strong and faint KIT protein staining, respectively, at two different sites. A single point mutation (c1727 T>C) was detected in DNA extracted from both sites, and a further deletion mutation (c1678_1680 del GTT) was detected in DNA from the site with strong KIT protein staining. Cloning analysis indicated that the point mutation and the deletion were present on different alleles.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20180082     DOI： 10.1007/s00595-008-4029-7

Source DB:  PubMed          Journal:  Surg Today        ISSN： 0941-1291            Impact factor:   2.549


  7 in total

1.  KIT activation is a ubiquitous feature of gastrointestinal stromal tumors.

Authors:  B P Rubin; S Singer; C Tsao; A Duensing; M L Lux; R Ruiz; M K Hibbard; C J Chen; S Xiao; D A Tuveson; G D Demetri; C D Fletcher; J A Fletcher
Journal:  Cancer Res       Date:  2001-11-15       Impact factor: 12.701

Review 2.  Imatinib and gastrointestinal stromal tumors: Where do we go from here?

Authors:  Ugo De Giorgi; Jaap Verweij
Journal:  Mol Cancer Ther       Date:  2005-03       Impact factor: 6.261

3.  Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors.

Authors:  S Hirota; K Isozaki; Y Moriyama; K Hashimoto; T Nishida; S Ishiguro; K Kawano; M Hanada; A Kurata; M Takeda; G Muhammad Tunio; Y Matsuzawa; Y Kanakura; Y Shinomura; Y Kitamura
Journal:  Science       Date:  1998-01-23       Impact factor: 47.728

4.  Gastrointestinal stromal tumor of the rectum resected by laparoscopic surgery: report of a case.

Authors:  Takatoshi Nakamura; Atsushi Ihara; Hiroyuki Mitomi; Yukihito Kokuba; Takeo Sato; Heita Ozawa; Kazuhiko Hatade; Wataru Onozato; Masahiko Watanabe
Journal:  Surg Today       Date:  2007-10-25       Impact factor: 2.549

5.  Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs).

Authors:  Anette Duensing; Fabiola Medeiros; Bryna McConarty; Nora E Joseph; Dipak Panigrahy; Samuel Singer; Christopher D M Fletcher; George D Demetri; Jonathan A Fletcher
Journal:  Oncogene       Date:  2004-05-13       Impact factor: 9.867

6.  Aberrant nuclear localization and gene mutation of beta-catenin in low-grade adenocarcinoma of fetal lung type: up-regulation of the Wnt signaling pathway may be a common denominator for the development of tumors that form morules.

Authors:  Yukio Nakatani; Katsuhiko Masudo; Yohei Miyagi; Yoshiaki Inayama; Naomi Kawano; Yukichi Tanaka; Keisuke Kato; Takaaki Ito; Hitoshi Kitamura; Yoji Nagashima; Shoji Yamanaka; Nobuo Nakamura; Jinyu Sano; Nobuo Ogawa; Naoki Ishiwa; Kenji Notohara; Milan Resl; Eugene J Mark
Journal:  Mod Pathol       Date:  2002-06       Impact factor: 7.842

7.  Mutations in exon 11 of c-Kit occur preferentially in malignant versus benign gastrointestinal stromal tumors and do not occur in leiomyomas or leiomyosarcomas.

Authors:  J Lasota; M Jasinski; M Sarlomo-Rikala; M Miettinen
Journal:  Am J Pathol       Date:  1999-01       Impact factor: 4.307
  7 in total
  1 in total

1.  Small bud of probable gastrointestinal stromal tumor within a laparoscopically-resected gastric schwannoma.

Authors:  Haruhiko Cho; Takafumi Watanabe; Toru Aoyama; Tsutomu Hayashi; Takanobu Yamada; Takashi Ogata; Takaki Yoshikawa; Akira Tsuburaya; Hironobu Sekiguchi; Yoshiyasu Nakamura; Yuji Sakuma; Yoichi Kameda; Yohei Miyagi
Journal:  Int J Clin Oncol       Date:  2011-08-18       Impact factor: 3.402
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.