PURPOSE: The objective of this study was to investigate the clinicopathological features and postoperative survival of primary colorectal signet-ring cell carcinoma. METHODS: Nineteen patients with primary colorectal signet-ring cell carcinoma were identified from a database of 5884 surgical patients with colorectal cancers treated surgically at Osaka University Hospital and affiliated hospitals between 1993 and 2007. The clinicopathological data of those patients were compared with those of 5792 patients with non-signet-ring cell colorectal carcinoma (5417 with well or moderately differentiated adenocarcinoma and 375 with poorly differentiated adenocarcinoma or mucinous carcinoma). RESULTS: All patients showed a tumor depth of over T3. Lymph node involvement occurred in 14 patients. Seven of 19 patients presented with distant metastasis at the time of diagnosis. The overall 5-year survival rate in primary signet-ring cell carcinoma was significantly lower at 24.1%, in comparison to 77.5% in well or moderately differentiated adenocarcinoma and 57.7% in poorly differentiated adenocarcinoma or mucinous carcinoma. Likewise, the postoperative survival in Stage III was also significantly worse. On the other hand, no significant difference was observed in Stage II or IV. CONCLUSION: The most important feature of primary colorectal signet-ring cell carcinoma is the advanced stage at the time of diagnosis. In addition, the postoperative survival is worse than for other types of colorectal cancer.
PURPOSE: The objective of this study was to investigate the clinicopathological features and postoperative survival of primary colorectal signet-ring cell carcinoma. METHODS: Nineteen patients with primary colorectal signet-ring cell carcinoma were identified from a database of 5884 surgical patients with colorectal cancers treated surgically at Osaka University Hospital and affiliated hospitals between 1993 and 2007. The clinicopathological data of those patients were compared with those of 5792 patients with non-signet-ring cell colorectal carcinoma (5417 with well or moderately differentiated adenocarcinoma and 375 with poorly differentiated adenocarcinoma or mucinous carcinoma). RESULTS: All patients showed a tumor depth of over T3. Lymph node involvement occurred in 14 patients. Seven of 19 patients presented with distant metastasis at the time of diagnosis. The overall 5-year survival rate in primary signet-ring cell carcinoma was significantly lower at 24.1%, in comparison to 77.5% in well or moderately differentiated adenocarcinoma and 57.7% in poorly differentiated adenocarcinoma or mucinous carcinoma. Likewise, the postoperative survival in Stage III was also significantly worse. On the other hand, no significant difference was observed in Stage II or IV. CONCLUSION: The most important feature of primary colorectal signet-ring cell carcinoma is the advanced stage at the time of diagnosis. In addition, the postoperative survival is worse than for other types of colorectal cancer.
Authors: C G Moertel; T R Fleming; J S Macdonald; D G Haller; J A Laurie; P J Goodman; J S Ungerleider; W A Emerson; D C Tormey; J H Glick Journal: N Engl J Med Date: 1990-02-08 Impact factor: 91.245
Authors: Christoph Jakob Ackermann; Ulrich Guller; Wolfram Jochum; Bruno M Schmied; Rene Warschkow Journal: Int J Colorectal Dis Date: 2018-06-07 Impact factor: 2.571
Authors: John R Hyngstrom; Chung-Yuan Hu; Yan Xing; Y Nancy You; Barry W Feig; John M Skibber; Miguel A Rodriguez-Bigas; Janice N Cormier; George J Chang Journal: Ann Surg Oncol Date: 2012-04-04 Impact factor: 5.344
Authors: Alia M Attia; Ashraf Farrag; Noha M Attia; Lamiaa Mr Khalaf; Hesham M Hassan; Mahmoud Gamal Ameen; Ebrahim Aboeleuon; Sanaa Saber Abd El-Raheem; Ahmed Mahran; Ahmed Mubarak Hefni Journal: Am J Cancer Res Date: 2022-03-15 Impact factor: 6.166
Authors: Ho-Su Lee; Jae Seung Soh; Seohyun Lee; Jung Ho Bae; Kyung-Jo Kim; Byong Duk Ye; Jeong-Sik Byeon; Seung-Jae Myung; Suk-Kyun Yang; Sun A Kim; Young Soo Park; Seok-Byung Lim; Jin Cheon Kim; Chang Sik Yu; Dong-Hoon Yang Journal: Intest Res Date: 2015-10-15