Literature DB >> 20179336

Coiled-coil conformation of a pentamidine-DNA complex.

Tadeo Moreno1, Joan Pous, Juan A Subirana, J Lourdes Campos.   

Abstract

The coiled-coil structure formed by the complex of the DNA duplex d(ATATATATAT)(2) with pentamidine is presented. The duplex was found to have a mixed structure containing Watson-Crick and Hoogsteen base pairs. The drug stabilizes the coiled coil through the formation of cross-links between neighbouring duplexes. The central part of the drug is found in the minor groove as expected, whereas the charged terminal amidine groups protrude and interact with phosphates from neighbouring molecules. The formation of cross-links may be related to the biological effects of pentamidine, which is used as an antiprotozoal agent in trypanosomiasis, leishmaniasis and pneumonias associated with AIDS. The DNA sequence that was used is highly abundant in most eukaryotic genomes. However, very few data are available on DNA sequences which only contain A.T base pairs.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20179336     DOI： 10.1107/S0907444909055693

Source DB:  PubMed          Journal:  Acta Crystallogr D Biol Crystallogr        ISSN： 0907-4449


  9 in total

1.  Functional and structural analysis of AT-specific minor groove binders that disrupt DNA-protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast.

Authors:  Cinthia R Millan; Francisco J Acosta-Reyes; Laura Lagartera; Godwin U Ebiloma; Leandro Lemgruber; J Jonathan Nué Martínez; Núria Saperas; Christophe Dardonville; Harry P de Koning; J Lourdes Campos
Journal:  Nucleic Acids Res       Date:  2017-08-21       Impact factor: 16.971

Review 2.  The many twists and turns of DNA: template, telomere, tool, and target.

Authors:  Martin Egli; Pradeep S Pallan
Journal:  Curr Opin Struct Biol       Date:  2010-04-08       Impact factor: 6.809

Review 3.  Structure-based DNA-targeting strategies with small molecule ligands for drug discovery.

Authors:  Jia Sheng; Jianhua Gan; Zhen Huang
Journal:  Med Res Rev       Date:  2013-04-30       Impact factor: 12.944

4.  Structure of the DNA duplex d(ATTAAT)2 with Hoogsteen hydrogen bonds.

Authors:  Francisco J Acosta-Reyes; Elida Alechaga; Juan A Subirana; J Lourdes Campos
Journal:  PLoS One       Date:  2015-03-17       Impact factor: 3.240

Review 5.  Recent Advances in Developing Small Molecules Targeting Nucleic Acid.

Authors:  Maolin Wang; Yuanyuan Yu; Chao Liang; Aiping Lu; Ge Zhang
Journal:  Int J Mol Sci       Date:  2016-05-30       Impact factor: 5.923

Review 6.  An overview of recent advances in duplex DNA recognition by small molecules.

Authors:  Sayantan Bhaduri; Nihar Ranjan; Dev P Arya
Journal:  Beilstein J Org Chem       Date:  2018-05-16       Impact factor: 2.883

Review 7.  MAOS and medicinal chemistry: some important examples from the last years.

Authors:  Nailton M Nascimento-Júnior; Arthur E Kümmerle; Eliezer J Barreiro; Carlos A M Fraga
Journal:  Molecules       Date:  2011-11-07       Impact factor: 4.411

8.  Multi-spectroscopic, thermodynamic, and molecular docking/dynamic approaches for characterization of the binding interaction between calf thymus DNA and palbociclib.

Authors:  Galal Magdy; Moataz A Shaldam; Fathalla Belal; Heba Elmansi
Journal:  Sci Rep       Date:  2022-08-30       Impact factor: 4.996

9.  In and out of the minor groove: interaction of an AT-rich DNA with the drug CD27.

Authors:  Francisco J Acosta-Reyes; Christophe Dardonville; Harry P de Koning; Manal Natto; Juan A Subirana; J Lourdes Campos
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2014-05-24
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.