| Literature DB >> 20178831 |
Lei Wang1, Ji-feng Guo, Wen-wen Zhang, Qian Xu, Xing Zuo, Chang-he Shi, Lin-zi Luo, Jia Liu, Liang Hu, Ya-cen Hu, Lu She, Hong Jiang, Xin-xiang Yan, Kun Xia, Qian Pan, Bei-sha Tang.
Abstract
The Grb10-Interacting GYF Protein-2 gene (GIGYF2), located in the chromosomal region 2q36-q37, has been reported as a PARK11 gene with a causal role in familial Parkinson's disease (PD) in Italian and French populations. However, there is no comprehensive study of GIGYF2 gene conducted in Chinese patients with PD from mainland China. The 27 coding exons and intron/exon boundaries of the GIGYF2 gene were sequenced in 300 sporadic patients with Parkinson's disease. Eight heterozygous and one homozygous novel missense variants were identified in nine patients with PD, and not in 300 controls. p.Leu580Phe locates in the GYF domain and might interrupt the potentially function of GIGYF2 protein. Another variant Gln979stop encodes a truncated protein. In conclusion, we identified nine novel variants in GIGYF2 gene, which might be associated with PD in the Chinese population.Entities:
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Year: 2010 PMID： 20178831 DOI： 10.1016/j.neulet.2010.02.037
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046