Literature DB >> 20178747

Nfix regulates fetal-specific transcription in developing skeletal muscle.

Graziella Messina1, Stefano Biressi, Stefania Monteverde, Alessandro Magli, Marco Cassano, Laura Perani, Elena Roncaglia, Enrico Tagliafico, Linda Starnes, Christine E Campbell, Milena Grossi, David J Goldhamer, Richard M Gronostajski, Giulio Cossu.   

Abstract

Skeletal myogenesis, like hematopoiesis, occurs in successive developmental stages that involve different cell populations and expression of different genes. We show here that the transcription factor nuclear factor one X (Nfix), whose expression is activated by Pax7 in fetal muscle, in turn activates the transcription of fetal specific genes such as MCK and beta-enolase while repressing embryonic genes such as slow myosin. In the case of the MCK promoter, Nfix forms a complex with PKC theta that binds, phosphorylates, and activates MEF2A. Premature expression of Nfix activates fetal and suppresses embryonic genes in embryonic muscle, whereas muscle-specific ablation of Nfix prevents fetal and maintains embryonic gene expression in the fetus. Therefore, Nfix acts as a transcriptional switch from embryonic to fetal myogenesis. 2010 Elsevier Inc. All rights reserved.

Entities:  

Mesh:

Substances:

Year:  2010        PMID: 20178747     DOI: 10.1016/j.cell.2010.01.027

Source DB:  PubMed          Journal:  Cell        ISSN: 0092-8674            Impact factor:   41.582


  78 in total

1.  DNA methylation shows genome-wide association of NFIX, RAPGEF2 and MSRB3 with gestational age at birth.

Authors:  Hwajin Lee; Andrew E Jaffe; Jason I Feinberg; Rakel Tryggvadottir; Shannon Brown; Carolina Montano; Martin J Aryee; Rafael A Irizarry; Julie Herbstman; Frank R Witter; Lynn R Goldman; Andrew P Feinberg; M Daniele Fallin
Journal:  Int J Epidemiol       Date:  2012-02       Impact factor: 7.196

Review 2.  Nuclear factor one transcription factors: Divergent functions in developmental versus adult stem cell populations.

Authors:  Lachlan Harris; Laura A Genovesi; Richard M Gronostajski; Brandon J Wainwright; Michael Piper
Journal:  Dev Dyn       Date:  2014-09-11       Impact factor: 3.780

Review 3.  The emerging role of protein kinase Cθ in cytoskeletal signaling.

Authors:  Izabela Michalczyk; Aleksander F Sikorski; Leszek Kotula; Richard P Junghans; Patrycja M Dubielecka
Journal:  J Leukoc Biol       Date:  2012-11-27       Impact factor: 4.962

Review 4.  Axial and limb muscle development: dialogue with the neighbourhood.

Authors:  Marianne Deries; Sólveig Thorsteinsdóttir
Journal:  Cell Mol Life Sci       Date:  2016-06-25       Impact factor: 9.261

5.  MiR-212-3p inhibits cell proliferation and promotes apoptosis by targeting nuclear factor IA in bladder cancer.

Authors:  Xiaoming Wu; Hao Chen; Gaoyue Zhang; Jianhui Wu; Wei Zhu; Yanqin Gu; Y I He
Journal:  J Biosci       Date:  2019-09       Impact factor: 1.826

6.  Connective tissue fibroblasts and Tcf4 regulate myogenesis.

Authors:  Sam J Mathew; Jody M Hansen; Allyson J Merrell; Malea M Murphy; Jennifer A Lawson; David A Hutcheson; Mark S Hansen; Melinda Angus-Hill; Gabrielle Kardon
Journal:  Development       Date:  2011-01       Impact factor: 6.868

Review 7.  Origin of vertebrate limb muscle: the role of progenitor and myoblast populations.

Authors:  Malea Murphy; Gabrielle Kardon
Journal:  Curr Top Dev Biol       Date:  2011       Impact factor: 4.897

8.  NFI transcription factors interact with FOXA1 to regulate prostate-specific gene expression.

Authors:  Magdalena M Grabowska; Amicia D Elliott; David J DeGraff; Philip D Anderson; Govindaraj Anumanthan; Hironobu Yamashita; Qian Sun; David B Friedman; David L Hachey; Xiuping Yu; Jonathan H Sheehan; Jung-Mo Ahn; Ganesh V Raj; David W Piston; Richard M Gronostajski; Robert J Matusik
Journal:  Mol Endocrinol       Date:  2014-05-06

9.  Genome-wide expression analysis and EMX2 gene expression in embryonic myoblasts committed to diverse skeletal muscle fiber type fates.

Authors:  Kristina Weimer; Jillian Theobald; Kenneth S Campbell; Karyn A Esser; Joseph X DiMario
Journal:  Dev Dyn       Date:  2013-06-24       Impact factor: 3.780

10.  Transcriptional regulation of intermediate progenitor cell generation during hippocampal development.

Authors:  Lachlan Harris; Oressia Zalucki; Ilan Gobius; Hannah McDonald; Jason Osinki; Tracey J Harvey; Alexandra Essebier; Diana Vidovic; Ivan Gladwyn-Ng; Thomas H Burne; Julian I Heng; Linda J Richards; Richard M Gronostajski; Michael Piper
Journal:  Development       Date:  2016-12-15       Impact factor: 6.868

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.