OBJECTIVE: We evaluated the accuracy of the diagnosis of celiac disease (CD) performed in the community clinical setting compared with that of an academic experienced center. MATERIALS: Original biopsy slides and reports used for diagnosis in the community setting and the CD serology were revised in 70 consecutive patients attending our institution for a second opinion. An expert team determined the final diagnosis unaware of the original consideration. RESULTS: The poor quality of samples made histology assessment by the expert pathologist uncertain in 8.7% of slides with CD external diagnosis. We detected a divergent diagnosis between the two practice settings in 46.3% of available cases with a significant overdiagnosis of CD in the community (p < 0.0001). Congruent serology results were demonstrated in 72.2% of cases. CONCLUSION: Our study detected a high rate of histopathological and serological misdiagnosis of CD in community practice which may have profound negative impact on patients.
OBJECTIVE: We evaluated the accuracy of the diagnosis of celiac disease (CD) performed in the community clinical setting compared with that of an academic experienced center. MATERIALS: Original biopsy slides and reports used for diagnosis in the community setting and the CD serology were revised in 70 consecutive patients attending our institution for a second opinion. An expert team determined the final diagnosis unaware of the original consideration. RESULTS: The poor quality of samples made histology assessment by the expert pathologist uncertain in 8.7% of slides with CD external diagnosis. We detected a divergent diagnosis between the two practice settings in 46.3% of available cases with a significant overdiagnosis of CD in the community (p < 0.0001). Congruent serology results were demonstrated in 72.2% of cases. CONCLUSION: Our study detected a high rate of histopathological and serological misdiagnosis of CD in community practice which may have profound negative impact on patients.
Authors: Emilia Sugai; María L Moreno; Hui J Hwang; Ana Cabanne; Adriana Crivelli; Fabio Nachman; Horacio Vázquez; Sonia Niveloni; Julio Argonz; Roberto Mazure; Graciela La Motta; María E Caniggia; Edgardo Smecuol; Néstor Chopita; Juan C Gómez; Eduardo Mauriño; Julio C Bai Journal: World J Gastroenterol Date: 2010-07-07 Impact factor: 5.742
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Authors: Norelle R Reilly; Steffen Husby; David S Sanders; Peter H R Green Journal: Nat Rev Gastroenterol Hepatol Date: 2017-10-11 Impact factor: 46.802
Authors: Joyce Y Tung; Chuong B Do; David A Hinds; Amy K Kiefer; J Michael Macpherson; Arnab B Chowdry; Uta Francke; Brian T Naughton; Joanna L Mountain; Anne Wojcicki; Nicholas Eriksson Journal: PLoS One Date: 2011-08-17 Impact factor: 3.240
Authors: Leonid Shamban; Serge Sorser; Stan Naydin; Benjamin Lebwohl; Mousa Shukr; Charlotte Wiemann; Daniel Yevsyukov; Michael H Piper; Bradley Warren; Peter H R Green Journal: Endosc Int Open Date: 2017-12-06