BACKGROUND: Few data are available comparing homocysteine (Hcy) levels in patients with hypertension in different ethnic groups. OBJECTIVES: This study sought to determine whether there are associations of blood pressure and Hcy levels in patients with hypertension from Xinjiang Province, China. METHODS: We examined the serum total Hcy levels in a total of 451 Chinese of various ethnic groups (Han n=234 [51.9%], Uygur n=102 [22.6%], Kazak n=61 [13.5%], Hui n=54 [12.0%]) aged 18-78 years. Two groups of subjects were studied: 1) non-hypertensive, n=101; (2) hypertensive, n=350. We investigated the serum Hcy levels relationship with hypertension. RESULTS: Hcy levels of Kazak in no hypertension and hypertension patients were highest (11.9 +/- 9.8 vs 19.0 +/- 11.8 umol/L, respectively, unadjusted P=.004, adjusted P=.016). This pattern of higher Hcy values in hypertension patients was consistent across all ethnic groups even after adjustment (all P<0.05). The hypertension risks in the elevated Hcy (>13.9 umol/L) was 3.5 (95% CI, 2.2-5.4) times the normal Hcy (< or = 13.9 umol/L) (P<0.001). Even after adjustment for potential confounders, this difference remained 3.1 times higher (95% CI, 1.9-4.8) (P<.001). Bivariate correlation analysis revealed a statistically significant relationship of Hcy with systolic or diastolic blood pressure across all ethnic groups. CONCLUSION: This study confirms the existence of a significant association between hypertension and Hcy in Chinese population groups.
BACKGROUND: Few data are available comparing homocysteine (Hcy) levels in patients with hypertension in different ethnic groups. OBJECTIVES: This study sought to determine whether there are associations of blood pressure and Hcy levels in patients with hypertension from Xinjiang Province, China. METHODS: We examined the serum total Hcy levels in a total of 451 Chinese of various ethnic groups (Han n=234 [51.9%], Uygur n=102 [22.6%], Kazak n=61 [13.5%], Hui n=54 [12.0%]) aged 18-78 years. Two groups of subjects were studied: 1) non-hypertensive, n=101; (2) hypertensive, n=350. We investigated the serum Hcy levels relationship with hypertension. RESULTS:Hcy levels of Kazak in no hypertension and hypertensionpatients were highest (11.9 +/- 9.8 vs 19.0 +/- 11.8 umol/L, respectively, unadjusted P=.004, adjusted P=.016). This pattern of higher Hcy values in hypertensionpatients was consistent across all ethnic groups even after adjustment (all P<0.05). The hypertension risks in the elevated Hcy (>13.9 umol/L) was 3.5 (95% CI, 2.2-5.4) times the normal Hcy (< or = 13.9 umol/L) (P<0.001). Even after adjustment for potential confounders, this difference remained 3.1 times higher (95% CI, 1.9-4.8) (P<.001). Bivariate correlation analysis revealed a statistically significant relationship of Hcy with systolic or diastolic blood pressure across all ethnic groups. CONCLUSION: This study confirms the existence of a significant association between hypertension and Hcy in Chinese population groups.
Authors: Z Li; X Guo; S Chen; L Zheng; H Yang; G Sun; S Yu; W Li; L Zhou; J Wang; W Hu; Y Sun Journal: J Hum Hypertens Date: 2015-07-09 Impact factor: 3.012