Literature DB >> 2017776

Induction of chromosome changes by metal compounds in cultured CHO cells.

W Howard1, B Leonard, W Moody, T S Kochhar.   

Abstract

The effect of 4 metal salts on the induction of chromosome aberrations and sister chromatid exchange (SCE) in cultured Chinese hamster ovary (CHO) cells was investigated. It was observed that CdCl2, NiCl2, CrO3 and HgCl2 were effective in causing various types of chromosome aberrations. The percentages of abnormalities increased with increasing doses of the metals used. These metal compounds also raised the SCE rates compared to 5-bromo-2'-deoxyuridine controls. The importance of rapid screening of potentially hazardous metals is described.

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Year:  1991        PMID： 2017776     DOI： 10.1016/0378-4274(91)90105-f

Source DB:  PubMed          Journal:  Toxicol Lett        ISSN： 0378-4274            Impact factor:   4.372


  5 in total

1.  Enhanced production of micronuclei by hexavalent chromium in cultured CHO cells.

Authors:  W R Howard; S A Hoffman; T S Kochhar
Journal:  Bull Environ Contam Toxicol       Date:  1992-10       Impact factor: 2.151

Review 2.  Bioluminescence Color-Tuning Firefly Luciferases: Engineering and Prospects for Real-Time Intracellular pH Imaging and Heavy Metal Biosensing.

Authors:  Vadim R Viviani; Gabriel F Pelentir; Vanessa R Bevilaqua
Journal:  Biosensors (Basel)       Date:  2022-06-10

3.  Induction of the human growth hormone gene placed under human hsp70 promoter control in mouse cells: a quantitative indicator of metal toxicity.

Authors:  M Fischbach; E Sabbioni; P Bromley
Journal:  Cell Biol Toxicol       Date:  1993 Apr-Jun       Impact factor: 6.691

4.  Biomonitoring results and cytogenetic markers among harbour workers with potential exposure to river silt aerosols.

Authors:  R Wegner; K Radon; R Heinrich-Ramm; B Seemann; A Riess; F Koops; B Poschadel; D Szadkowski
Journal:  Occup Environ Med       Date:  2004-03       Impact factor: 4.402

5.  Use of genetic toxicology data in U.S. EPA risk assessment: the mercury study report as an example.

Authors:  R Schoeny
Journal:  Environ Health Perspect       Date:  1996-05       Impact factor: 9.031
  5 in total

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