Literature DB >> 20177626

Efficient, direct alpha-methylenation of carbonyls mediated by diisopropylammonium trifluoroacetate.

Alejandro Bugarin1, Kyle D Jones, Brian T Connell.   

Abstract

A very efficient method for the direct alpha-methylenation of carbonyl compounds, with yields up to 99%, utilizing paraformaldehyde, diisopropylammonium trifluoroacetate, and catalytic acid or base, is presented.

Entities:  

Year:  2010        PMID： 20177626     DOI： 10.1039/b924577d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  2 in total

1.  Asymmetric synthesis of the aminocyclitol pactamycin, a universal translocation inhibitor.

Authors:  Robert J Sharpe; Justin T Malinowski; Jeffrey S Johnson
Journal:  J Am Chem Soc       Date:  2013-11-18       Impact factor: 15.419

2.  Concise Six-Step Asymmetric Approach to Ramelteon from an Acetophenone Derivative Using Ir, Rh, Cu, and Ni Catalysis.

Authors:  Jérôme Cluzeau; Ulrike Nettekoven; Miroslav Planinc Kovačevič; Zdenko Časar
Journal:  J Org Chem       Date:  2021-09-30       Impact factor: 4.354
  2 in total

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