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Literature DB >> 20176158

[The endogenous opioid system and drug addiction].

Abstract

Drug addiction is a chronic brain disorder leading to complex adaptive changes within the brain reward circuits. Several neurotransmitters, including the endogenous opioid system are involved in these changes. The opioid system plays a pivotal role in different aspects of addiction. Thus, opioid receptors and endogenous opioid peptides are largely distributed in the mesolimbic system and modulate dopaminergic activity within the reward circuits. Opioid receptors and peptides are selectively involved in several components of the addictive processes induced by opioids, cannabinoids, psychostimulants, alcohol and nicotine. This review is focused on the contribution of each component of the endogenous opioid system in the addictive properties of the different drugs of abuse. Copyright 2010 Elsevier Masson SAS. All rights reserved.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Endorphins

Year: 2010 PMID： 20176158 PMCID： PMC3444724 DOI： 10.1016/j.pharma.2009.12.001

Source DB: PubMed Journal: Ann Pharm Fr ISSN： 0003-4509

111 in total

1. Autoradiographic localization of [3H]nociceptin binding sites from telencephalic to mesencephalic regions of the mouse brain.

Authors: S Florin; I Leroux-Nicollet; J C Meunier; J Costentin
Journal: Neurosci Lett Date: 1997-07-11 Impact factor: 3.046

2. The development of cross-tolerance between morphine and nicotine in mice.

Authors: M R Zarrindast; M R Khoshayand; B Shafaghi
Journal: Eur Neuropsychopharmacol Date: 1999-03 Impact factor: 4.600

3. Characterization of the mu and delta opioid receptors in the brain of the C57BL/6 and DBA/2 mice, selected for their differences in voluntary ethanol consumption.

Authors: J P de Waele; C Gianoulakis
Journal: Alcohol Clin Exp Res Date: 1997-06 Impact factor: 3.455

4. A potent and selective endogenous agonist for the mu-opiate receptor.

Authors: J E Zadina; L Hackler; L J Ge; A J Kastin
Journal: Nature Date: 1997-04-03 Impact factor: 49.962

5. DAMGO and DPDPE facilitation of brain stimulation reward thresholds is blocked by the dopamine antagonist cis-flupenthixol.

Authors: C L Duvauchelle; S M Fleming; C Kornetsky
Journal: Neuropharmacology Date: 1997-08 Impact factor: 5.250

6. Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mu1 opioid receptor mechanism.

Authors: G Tanda; F E Pontieri; G Di Chiara
Journal: Science Date: 1997-06-27 Impact factor: 47.728

7. Increased gabaergic input to ventral tegmental area dopaminergic neurons associated with decreased cocaine reinforcement in mu-opioid receptor knockout mice.

Authors: D S Mathon; H M B Lesscher; M A F M Gerrits; A Kamal; J E Pintar; A G P Schuller; B M Spruijt; J P H Burbach; M P Smidt; J M van Ree; G M J Ramakers
Journal: Neuroscience Date: 2005 Impact factor: 3.590

8. Fentanyl increases dopamine release in rat nucleus accumbens: involvement of mesolimbic mu- and delta-2-opioid receptors.

Authors: Y Yoshida; S Koide; N Hirose; K Takada; K Tomiyama; N Koshikawa; A R Cools
Journal: Neuroscience Date: 1999 Impact factor: 3.590

[The endogenous opioid system and drug addiction].

1. Autoradiographic localization of [3H]nociceptin binding sites from telencephalic to mesencephalic regions of the mouse brain.

2. The development of cross-tolerance between morphine and nicotine in mice.

3. Characterization of the mu and delta opioid receptors in the brain of the C57BL/6 and DBA/2 mice, selected for their differences in voluntary ethanol consumption.

4. A potent and selective endogenous agonist for the mu-opiate receptor.

5. DAMGO and DPDPE facilitation of brain stimulation reward thresholds is blocked by the dopamine antagonist cis-flupenthixol.

6. Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mu1 opioid receptor mechanism.

7. Increased gabaergic input to ventral tegmental area dopaminergic neurons associated with decreased cocaine reinforcement in mu-opioid receptor knockout mice.

8. Fentanyl increases dopamine release in rat nucleus accumbens: involvement of mesolimbic mu- and delta-2-opioid receptors.

9. Naloxone challenge in smokers. Preliminary evidence of an opioid component in nicotine dependence.

10. Delta9-tetrahydrocannabinol decreases somatic and motivational manifestations of nicotine withdrawal in mice.

Review 1. The opioid receptors as targets for drug abuse medication.

2. Genesis of the Heroin-Induced Addictive Process: Articulation Between Psychodynamic and Neurobiological Theories.