| Literature DB >> 20176151 |
Yuanzi Wu1, Sean R Coyer, Hongwei Ma, Andrés J García.
Abstract
Poly(dimethylsiloxane) (PDMS) is the choice of material for a wide range of biological and non-biological applications because of its chemical inertness, non-toxicity, ease of handling and commercial availability. However, PDMS exhibits uncontrolled protein adsorption and cell adhesion and it has proved difficult to functionalize to present bioactive ligands. We present a facile strategy for functional surface modification of PDMS using commercial reagents to engineer polymer brushes of oligo(ethylene glycol) methacrylate that prevent cell adhesion and can be functionalized to display bioadhesive ligands. The polymer brushes resist biofouling and prevent cell adhesion and bioadhesive peptides can be tethered either uniformly or constrained to micropatterned domains using standard peptide chemistry approaches. This approach is relevant to various biomedical and biotechnological applications. Copyright 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20176151 PMCID： PMC2883028 DOI： 10.1016/j.actbio.2010.02.025
Source DB: PubMed Journal: Acta Biomater ISSN： 1742-7061 Impact factor: 8.947