| Literature DB >> 20175969 |
Laurence Van Overtvelt1, Helene Moussu, Stéphane Horiot, Sandrine Samson, Vincent Lombardi, Laurent Mascarell, Ariane van de Moer, Raphaëlle Bourdet-Sicard, Philippe Moingeon.
Abstract
We compared immunomodulatory properties of 11 strains of lactic acid bacteria as well as their capacity to enhance sublingual immunotherapy efficacy in a murine asthma model. Two types of bacterial strains were identified, including: (i) potent inducers of IL-12p70 and IL-10 in dendritic cells, supporting IFN-gamma and IL-10 production in CD4+ T cells such as Lactobacillus helveticus; (ii) pure Th1 inducers such as L. casei. Sublingual administration in ovalbumin-sensitized mice of L. helveticus, but not L. casei, reduced airways hyperresponsiveness, bronchial inflammation and proliferation of specific T cells in cervical lymph nodes. Thus, probiotics acting as a Th1/possibly Treg, but not Th1 adjuvant, potentiate tolerance induction via the sublingual route. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
Mesh：
Substances：
Year: 2010 PMID： 20175969 DOI： 10.1016/j.vaccine.2010.02.009
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641