Literature DB >> 20173751

Two-photon uncaging of gamma-aminobutyric acid in intact brain tissue.

Masanori Matsuzaki1, Graham C R Ellis-Davies2, Tatsuya Hayama1, Haruo Kasai1.   

Abstract

We have synthesized a photosensitive (or caged) 4-carboxymethoxy-5,7-dinitroindolinyl (CDNI) derivative of gamma-aminobutyric acid (GABA). Two-photon excitation of CDNI-GABA produced rapid activation of GABAergic currents in neurons in brain slices with an axial resolution of approximately 2 mum and enabled high-resolution functional mapping of GABA-A receptors. Two-photon uncaging of GABA, the main inhibitory neurotransmitter, should allow detailed studies of receptor function and synaptic integration with subcellular precision.

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Year:  2010        PMID： 20173751      PMCID： PMC4104925          DOI： 10.1038/nchembio.321

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  22 in total

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