Literature DB >> 20172719

Novel powerful water-soluble lipid immunoadjuvants inducing mouse dendritic cell maturation and B cell proliferation using TLR2 pathway.

Maria Vittoria Spanedda1, Béatrice Heurtault, Steffen Weidner, Corinne Baehr, Emmanuelle Boeglin, Julien Beyrath, Sara Milosevic, Line Bourel-Bonnet, Sylvie Fournel, Benoît Frisch.   

Abstract

Four novel water-soluble lipid immunoadjuvants were designed, synthesized and characterized by MS and NMR. They all induce mouse dendritic cell maturation and B cell proliferation. We demonstrate that in spite of the chemical modification, the four compounds remain TLR2 agonists. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20172719     DOI： 10.1016/j.bmcl.2010.01.146

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

Review 1.  Strategies for designing synthetic immune agonists.

Authors:  Tom Y-H Wu
Journal:  Immunology       Date:  2016-07-11       Impact factor: 7.397

2.  Design and development of stable, water-soluble, human Toll-like receptor 2 specific monoacyl lipopeptides as candidate vaccine adjuvants.

Authors:  Deepak B Salunke; Seth W Connelly; Nikunj M Shukla; Alec R Hermanson; Lauren M Fox; Sunil A David
Journal:  J Med Chem       Date:  2013-07-10       Impact factor: 7.446

3.  Toll-like receptor agonists synergize with CD40L to induce either proliferation or plasma cell differentiation of mouse B cells.

Authors:  Emmanuelle Boeglin; Cristian R Smulski; Susana Brun; Sara Milosevic; Pascal Schneider; Sylvie Fournel
Journal:  PLoS One       Date:  2011-10-03       Impact factor: 3.240

4.  Simplified Monopalmitoyl Toll-like Receptor 2 Ligand Mini-UPam for Self-Adjuvanting Neoantigen-Based Synthetic Cancer Vaccines.

Authors:  Thomas C van den Ende; Jeroen M M Heuts; Geoffroy P P Gential; Marten Visser; Michel J van de Graaff; Nataschja I Ho; Wim Jiskoot; A Rob P M Valentijn; Nico J Meeuwenoord; Herman S Overkleeft; Jeroen D C Codée; Sjoerd H van der Burg; Els M E Verdegaal; Gijsbert A van der Marel; Ferry Ossendorp; Dmitri V Filippov
Journal:  Chembiochem       Date:  2020-12-22       Impact factor: 3.164

5.  Phytol-derived novel isoprenoid immunostimulants.

Authors:  Roshni Roy Chowdhury; Swapan K Ghosh
Journal:  Front Immunol       Date:  2012-03-22       Impact factor: 7.561
  5 in total

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