| Literature DB >> 20172305 |
M A Zaoualí1, I Ben Mosbah, H Ben Abdennebi, M Calvo, E Boncompagni, O Boillot, C Peralta, J Roselló-Catafau.
Abstract
Institute Georges Lopez preservation solution (IGL-1) has been demonstrated to be useful for fatty liver preservation. The mechanisms responsible for this effective graft protection against ischemia-reperfusion injury are pivotal actions on generation of nitric oxide a diffusible molecule with vasodilator properties, that facilitates the up-regulation of other well-known cytoprotective genes, such as hypoxia-inducible factor-1 alpha (HIF-1alpha) and heme-oxygenase 1 (HO-1). During normoxic reperfusion, the presence of nitric oxide permits HIF-1alpha accumulation to inhibit prolyl-hydoxylases, thus promoting an additional overexpression of the HO-1 in steatotic and nonsteatotic graft livers preserved in IGL-1.Entities:
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Year: 2010 PMID： 20172305 DOI： 10.1016/j.transproceed.2009.12.035
Source DB: PubMed Journal: Transplant Proc ISSN： 0041-1345 Impact factor: 1.066