| Literature DB >> 20171954 |
Yukitoshi Takemura1, Motohiko Satoh, Kiyotoshi Satoh, Hironobu Hamada, Yoshitaka Sekido, Shunichiro Kubota.
Abstract
Malignant mesothelioma is an asbestos-related fatal disease with no effective cure. Recently, high dose of ascorbate in cancer treatment has been reexamined. We studied whether high dose of ascorbic acid induced cell death of four human mesothelioma cell lines. High dose of ascorbic acid induced cell death of all mesothelioma cell lines in a dose-dependent manner. We further clarified the cell killing mechanism that ascorbic acid induced reactive oxygen species and impaired mitochondrial membrane potential. In vivo experiment, intravenous administration of ascorbic acid significantly decreased the growth rate of mesothelioma tumor inoculated in mice. These data suggest that ascorbic acid may have benefits for patients with mesothelioma. 2010 Elsevier Inc. All rights reserved.Entities:
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Year: 2010 PMID： 20171954 DOI： 10.1016/j.bbrc.2010.02.012
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575