| Literature DB >> 201719 |
B R Smith, G A Pyle, V B Petersen, R Hall.
Abstract
Thyroid-stimulating antibodies (TSAb) were found to inhibit the binding of labelled thyrotrophin (TSH) to thyroid membranes in a dose-dependent manner and this effect was localized in the Fab part of the TSAb molecule. Analysis of the binding data suggested that TSAb and TSH bound to the same receptor site. Production of cyclic AMP by the thyroid membranes was stimulated by TSAb and TSAb-Fab with a similar time course to that observed with TSH. Kinetic studies indicated that the binding of TSAb to the thyroid membranes was not rate-limiting in the process of stimulation of cyclic AMP production.Entities:
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Year: 1977 PMID： 201719 DOI： 10.1677/joe.0.0750401
Source DB: PubMed Journal: J Endocrinol ISSN： 0022-0795 Impact factor: 4.286