OBJECTIVE: The chromosome 3q26 region is a biomarker for cervical cancer. Women with low-grade squamous intraepithelial lesions (LSIL) currently are referred for immediate colposcopy. The objective of this study was to determine the negative predictive value of the 3q26 amplification test for the persistence or regression of LSIL. STUDY DESIGN: Archival thin layer cytologic slides of 47 women (14-67 years old) with LSIL were linked to histologic and cytologic end points. To determine 3q status, the slides were hybridized for the chromosome 3q26 region and for the centromere of chromosome 7, as a control, with the use of the standard fluorescent in situ hybridization methods. RESULTS: The negative predictive value of 3q26 gain for the development of cervical intraepithelial neoplasia grade 2/3 within 1 year was 93% (95% confidence interval, 68- 100); after 21 months, its negative predictive value was 100% (95% confidence interval, 29-100). CONCLUSION: The 3q26 gain might help identify women with LSIL who do not need colposcopy. Copyright 2010 Mosby, Inc. All rights reserved.
OBJECTIVE: The chromosome 3q26 region is a biomarker for cervical cancer. Women with low-grade squamous intraepithelial lesions (LSIL) currently are referred for immediate colposcopy. The objective of this study was to determine the negative predictive value of the 3q26 amplification test for the persistence or regression of LSIL. STUDY DESIGN: Archival thin layer cytologic slides of 47 women (14-67 years old) with LSIL were linked to histologic and cytologic end points. To determine 3q status, the slides were hybridized for the chromosome 3q26 region and for the centromere of chromosome 7, as a control, with the use of the standard fluorescent in situ hybridization methods. RESULTS: The negative predictive value of 3q26 gain for the development of cervical intraepithelial neoplasia grade 2/3 within 1 year was 93% (95% confidence interval, 68- 100); after 21 months, its negative predictive value was 100% (95% confidence interval, 29-100). CONCLUSION: The 3q26 gain might help identify women with LSIL who do not need colposcopy. Copyright 2010 Mosby, Inc. All rights reserved.
Authors: Patricia Luhn; Jane Houldsworth; Lynnette Cahill; Mark Schiffman; Philip E Castle; Rosemary E Zuna; S Terence Dunn; Michael A Gold; Joan Walker; Nicolas Wentzensen Journal: Gynecol Oncol Date: 2013-06-13 Impact factor: 5.482
Authors: Maximilian Linxweiler; Florian Bochen; Bernhard Schick; Silke Wemmert; Basel Al Kadah; Markus Greiner; Andrea Hasenfus; Rainer-Maria Bohle; Ingolf Juhasz-Böss; Erich-Franz Solomayer; Zoltan Ferenc Takacs Journal: BMC Cancer Date: 2016-08-23 Impact factor: 4.430
Authors: Erica R Heitmann; Kamani M Lankachandra; Jeff Wall; George D Harris; Hollie J McKinney; G Reza Jalali; Yogita Verma; Eric Kershnar; Michael W Kilpatrick; Petros Tsipouras; Diane M Harper Journal: PLoS One Date: 2012-07-06 Impact factor: 3.240
Authors: Margot M Koeneman; Irene T Ovestad; Emiel A M Janssen; Monique Ummelen; Roy F P M Kruitwagen; Anton H Hopman; Arnold J Kruse Journal: Pathol Oncol Res Date: 2018-10-25 Impact factor: 3.201