Literature DB >> 20171092

Stimulation of cephalosporin C production in Acremonium chrysogenum M35 by glycerol.

Hyun Yong Shin1, Jin Young Lee, You Ree Jung, Seung Wook Kim.   

Abstract

In this study, the effects of glycerol on cephalosporin C production by Acremonium chrysogenum M35 were evaluated. The addition of glycerol increased cephalosporin production by up to 12-fold. Glycerol caused the upregulation of the transcription of the isopenicillin synthase (pcbC) and transporter (cefT) genes in early exponential phase, and affected the cell morphology since hyphal fragments differentiated into arthrospores. These results indicate that glycerol effectively enhances cephalosporin C production via stimulation of cell differentiation. (c) 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20171092     DOI： 10.1016/j.biortech.2010.01.095

Source DB:  PubMed          Journal:  Bioresour Technol        ISSN： 0960-8524            Impact factor:   9.642


  3 in total

1.  Production of cephalosporin C using crude glycerol in fed-batch culture of Acremonium chrysogenum M35.

Authors:  Hyun Yong Shin; Jin Young Lee; Han Suk Choi; Ja Hyun Lee; Seung Wook Kim
Journal:  J Microbiol       Date:  2011-11-09       Impact factor: 3.422

2.  Improved FK506 production by the precursors and product-tolerant mutant of Streptomyces tsukubaensis based on genome shuffling and dynamic fed-batch strategies.

Authors:  Wenjie Du; Di Huang; Menglei Xia; Jianping Wen; Ming Huang
Journal:  J Ind Microbiol Biotechnol       Date:  2014-05-01       Impact factor: 3.346

Review 3.  Carbon catabolite regulation of secondary metabolite formation, an old but not well-established regulatory system.

Authors:  Beatriz Ruiz-Villafán; Rodrigo Cruz-Bautista; Monserrat Manzo-Ruiz; Ajit Kumar Passari; Karen Villarreal-Gómez; Romina Rodríguez-Sanoja; Sergio Sánchez
Journal:  Microb Biotechnol       Date:  2021-03-06       Impact factor: 5.813
  3 in total

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