Literature DB >> 20170686

Regulation of cortical acetylcholine release: insights from in vivo microdialysis studies.

Jim R Fadel1.   

Abstract

Acetylcholine release links the activity of presynaptic neurons with their postsynaptic targets and thus represents the intercellular correlate of cholinergic neurotransmission. Here, we review the regulation and functional significance of acetylcholine release in the mammalian cerebral cortex, with a particular emphasis on information derived from in vivo microdialysis studies over the past three decades. This information is integrated with anatomical and behavioral data to derive conclusions regarding the role of cortical cholinergic transmission in normal behavioral and how its dysregulation may contribute to cognitive correlates of several neuropsychiatric conditions. Some unresolved issues regarding the regulation and significance of cortical acetylcholine release and the promise of new methodology for advancing our knowledge in this area are also briefly discussed.
Copyright © 2010 Elsevier B.V. All rights reserved.

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Year:  2010        PMID: 20170686      PMCID: PMC2925059          DOI: 10.1016/j.bbr.2010.02.022

Source DB:  PubMed          Journal:  Behav Brain Res        ISSN: 0166-4328            Impact factor:   3.332


  168 in total

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