Literature DB >> 20167999

Decreased plasma levels of darunavir/ritonavir in a vertically infected pregnant woman carrying multiclass-resistant HIV type-1.

Carmela Pinnetti1, Enrica Tamburrini, Enzo Ragazzoni, Andrea De Luca, Pierluigi Navarra.   

Abstract

We report a case of a vertically infected woman treated with darunavir/ritonavir plus a standard backbone before pregnancy. The analysis of darunavir/ritonavir concentrations in peripheral maternal plasma throughout pregnancy, as well as in umbilical cord blood at delivery, showed low levels of darunavir in the mother and limited transfer across the placenta.

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Year:  2010        PMID： 20167999     DOI： 10.3851/IMP1473

Source DB:  PubMed          Journal:  Antivir Ther        ISSN： 1359-6535


  4 in total

1.  Placental transfer of darunavir in an ex vivo human cotyledon perfusion model.

Authors:  Laurent Mandelbrot; Dominique Duro; Emilie Belissa; Gilles Peytavin
Journal:  Antimicrob Agents Chemother       Date:  2014-06-30       Impact factor: 5.191

2.  Pharmacokinetics of Once Versus Twice Daily Darunavir in Pregnant HIV-Infected Women.

Authors:  Alice Stek; Brookie M Best; Jiajia Wang; Edmund V Capparelli; Sandra K Burchett; Regis Kreitchmann; Kittipong Rungruengthanakit; Tim R Cressey; Lynne M Mofenson; Elizabeth Smith; David Shapiro; Mark Mirochnick
Journal:  J Acquir Immune Defic Syndr       Date:  2015-09-01       Impact factor: 3.731

Review 3.  Protecting the fetus against HIV infection: a systematic review of placental transfer of antiretrovirals.

Authors:  Shelley A McCormack; Brookie M Best
Journal:  Clin Pharmacokinet       Date:  2014-11       Impact factor: 6.447

4.  Total and unbound darunavir pharmacokinetics in pregnant women infected with HIV-1: results of a study of darunavir/ritonavir 600/100 mg administered twice daily.

Authors:  C D Zorrilla; R Wright; O O Osiyemi; S Yasin; B Baugh; K Brown; B Coate; P Verboven; J Mrus; R Falcon; T N Kakuda
Journal:  HIV Med       Date:  2013-06-03       Impact factor: 3.180
  4 in total

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