BACKGROUND AND OBJECTIVES: This study aimed to investigate the development of new-onset diabetes mellitus (NODM) in a prospective study of 97 nondiabetic uremic patients. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Included were 57 kidney recipients (Tx group, age 39 +/- 13 years) and 40 uremic patients remaining on the waiting list for kidney transplantation (uremic controls, age 47 +/- 11 years). All were examined at baseline before possible transplantation and after 12 months. The prevalence of diabetes, prediabetes, insulin sensitivity index (ISI), and insulin secretion index (Isecr) were estimated using an oral glucose tolerance test with measurements of plasma glucose and plasma insulin. RESULTS: One year after transplantation NODM was present in 14% (8 of 57) compared with 5% (2 of 40) in the uremic control group (P = 0.01). ISI in the Tx group deteriorated from 6.8 +/- 3.9 before transplantation to 4.9 +/- 2.8 at 12 months after transplantation (P = 0.005), and a slight increase in Isecr from 37 +/- 19 to 46 +/- 22 (P = 0.02) was seen. No significant changes occurred in the uremic controls (ISI was 7.9 +/- 5 and 8.5 +/- 5, and Isecr was 31 +/- 17 and 28 +/- 15). Using multivariate ordinal logistic regression, pre-Tx ISI and age predicted NODM (odds ratios: 0.82, P = 0.01 and 1.06, P = 0.02, respectively). CONCLUSIONS: One year after kidney transplantation, NODM was present in 14% of patients. This was mainly caused by an increase in insulin resistance and was observed despite improvement in insulin secretion.
BACKGROUND AND OBJECTIVES: This study aimed to investigate the development of new-onset diabetes mellitus (NODM) in a prospective study of 97 nondiabetic uremicpatients. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Included were 57 kidney recipients (Tx group, age 39 +/- 13 years) and 40 uremic patients remaining on the waiting list for kidney transplantation (uremic controls, age 47 +/- 11 years). All were examined at baseline before possible transplantation and after 12 months. The prevalence of diabetes, prediabetes, insulin sensitivity index (ISI), and insulin secretion index (Isecr) were estimated using an oral glucose tolerance test with measurements of plasma glucose and plasma insulin. RESULTS: One year after transplantation NODM was present in 14% (8 of 57) compared with 5% (2 of 40) in the uremic control group (P = 0.01). ISI in the Tx group deteriorated from 6.8 +/- 3.9 before transplantation to 4.9 +/- 2.8 at 12 months after transplantation (P = 0.005), and a slight increase in Isecr from 37 +/- 19 to 46 +/- 22 (P = 0.02) was seen. No significant changes occurred in the uremic controls (ISI was 7.9 +/- 5 and 8.5 +/- 5, and Isecr was 31 +/- 17 and 28 +/- 15). Using multivariate ordinal logistic regression, pre-Tx ISI and age predicted NODM (odds ratios: 0.82, P = 0.01 and 1.06, P = 0.02, respectively). CONCLUSIONS: One year after kidney transplantation, NODM was present in 14% of patients. This was mainly caused by an increase in insulin resistance and was observed despite improvement in insulin secretion.
Authors: N Sumrani; V Delaney; Z Ding; R Davis; P Daskalakis; E A Friedman; K M Butt; J H Hong Journal: Transplant Proc Date: 1991-02 Impact factor: 1.066
Authors: C B Drachenberg; D K Klassen; M R Weir; A Wiland; J C Fink; S T Bartlett; C B Cangro; S Blahut; J C Papadimitriou Journal: Transplantation Date: 1999-08-15 Impact factor: 4.939
Authors: J P Boudreaux; L McHugh; D M Canafax; N Ascher; D E Sutherland; W Payne; R L Simmons; J S Najarian; D S Fryd Journal: Transplantation Date: 1987-09 Impact factor: 4.939
Authors: Maria P Martinez Cantarin; Scott W Keith; Zhao Lin; Cataldo Doria; Adam M Frank; Warren R Maley; Carlo Ramirez; Costas D Lallas; Ashesh Shah; Scott A Waldman; Bonita Falkner Journal: Cardiorenal Med Date: 2016-05-18 Impact factor: 2.041
Authors: A Sharif; M Hecking; A P J de Vries; E Porrini; M Hornum; S Rasoul-Rockenschaub; G Berlakovich; M Krebs; A Kautzky-Willer; G Schernthaner; P Marchetti; G Pacini; A Ojo; S Takahara; J L Larsen; K Budde; K Eller; J Pascual; A Jardine; S J L Bakker; T G Valderhaug; T G Jenssen; S Cohney; M D Säemann Journal: Am J Transplant Date: 2014-08-06 Impact factor: 8.086
Authors: Martina Guthoff; Dorothea Vosseler; Julia Langanke; Silvio Nadalin; Alfred Königsrainer; Hans-Ulrich Häring; Andreas Fritsche; Nils Heyne Journal: PLoS One Date: 2015-09-23 Impact factor: 3.240
Authors: Manfred Hecking; Alexander Kainz; Johannes Werzowa; Michael Haidinger; Dominik Döller; Andrea Tura; Angelo Karaboyas; Walter H Hörl; Michael Wolzt; Adnan Sharif; Michael Roden; Ermanno Moro; Giovanni Pacini; Friedrich K Port; Marcus D Säemann Journal: Diabetes Care Date: 2013-05-08 Impact factor: 19.112