| Literature DB >> 20167379 |
Leos Kren1, Katarina Muckova, Eva Lzicarova, Marek Sova, Vaclav Vybihal, Tomas Svoboda, Pavel Fadrus, Martin Smrcka, Ondrej Slaby, Radek Lakomy, Petr Vanhara, Zdenka Krenova, Jaroslav Michalek.
Abstract
The possible role of immune-modulatory nonclassical molecules HLA-G and HLA-E in an anti-tumoral response and development of glioblastoma is not well characterized. In this study, we evaluated an expression of HLA-G and HLA-E by activated tumor infiltrating microglia/macrophages. We found production of HLA-G and HLA-E by tumor infiltrating activated microglia/macrophages in a majority of glioblastomas. We speculate that the expression of these molecules by activated microglia/CNS macrophages plays a role in the anti-tumoral immunity in the development of glioblastoma. Mechanisms of microglia-glioblastoma cell interactions with respect to the expression of these molecules deserves further study. Copyright 2010 Elsevier B.V. All rights reserved.Entities:
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Year: 2010 PMID： 20167379 DOI： 10.1016/j.jneuroim.2010.01.014
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478