Literature DB >> 20166943

Review of 5-HT4R ligands: state of art and clinical applications.

Ronan Bureau1, Michel Boulouard, François Dauphin, Frank Lezoualc'h, Sylvain Rault.   

Abstract

This article reviews the medicinal implications of 5-HT(4)R in the peripheral and central nervous systems, based on data from two hundred bibliographic references. An exhaustive compilation of molecules reported to be antagonists or agonists for 5-HT(4)R is presented, including chemical structures, binding properties and pharmacological profiles. In the last part of the review, some key concepts concerning structure-activity relationships are highlighted.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20166943     DOI： 10.2174/156802610791111551

Source DB:  PubMed          Journal:  Curr Top Med Chem        ISSN： 1568-0266            Impact factor:   3.295


  4 in total

Review 1.  Cross-Species Translational Findings in the Discriminative Stimulus Effects of Ethanol.

Authors:  Daicia C Allen; Matthew M Ford; Kathleen A Grant
Journal:  Curr Top Behav Neurosci       Date:  2018

2.  Zelnorm, an agonist of 5-Hydroxytryptamine 4-receptor, acts as a potential antitumor drug by targeting JAK/STAT3 signaling.

Authors:  Lei Zhang; Qiaoling Song; Xinxin Zhang; Li Li; Ximing Xu; Xiaohan Xu; Xiaoyu Li; Zhuoya Wang; Yuxi Lin; Xin Li; Mengyuan Li; Fan Su; Xin Wang; Peiju Qiu; Huashi Guan; Yu Tang; Wenfang Xu; Jinbo Yang; Chenyang Zhao
Journal:  Invest New Drugs       Date:  2019-05-14       Impact factor: 3.850

3.  A hybrid structural approach to analyze ligand binding by the serotonin type 4 receptor (5-HT4).

Authors:  Pius S Padayatti; Liwen Wang; Sayan Gupta; Tivadar Orban; Wenyu Sun; David Salom; Steven R Jordan; Krzysztof Palczewski; Mark R Chance
Journal:  Mol Cell Proteomics       Date:  2013-02-01       Impact factor: 5.911

4.  Synthesis and structure-affinity relationships of selective high-affinity 5-HT(4) receptor antagonists: application to the design of new potential single photon emission computed tomography tracers.

Authors:  Emmanuelle Dubost; Noé Dumas; Christine Fossey; Rosa Magnelli; Sabrina Butt-Gueulle; Céline Ballandonne; Daniel H Caignard; Fabienne Dulin; Jana Sopkova de-Oliveira Santos; Philippe Millet; Yves Charnay; Sylvain Rault; Thomas Cailly; Frederic Fabis
Journal:  J Med Chem       Date:  2012-11-09       Impact factor: 7.446
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.