Literature DB >> 20166108

Induced-fit binding of the macrocyclic noncovalent inhibitor TMC435 to its HCV NS3/NS4A protease target.

Maxwell D Cummings1, Jimmy Lindberg, Tse-I Lin, Herman de Kock, Oliver Lenz, Elisabet Lilja, Sara Felländer, Vera Baraznenok, Susanne Nyström, Magnus Nilsson, Lotta Vrang, Michael Edlund, Asa Rosenquist, Bertil Samuelsson, Pierre Raboisson, Kenneth Simmen.   

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Year:  2010        PMID： 20166108     DOI： 10.1002/anie.200906696

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  28 in total

1.  A macrocyclic HCV NS3/4A protease inhibitor interacts with protease and helicase residues in the complex with its full-length target.

Authors:  Nikolaus Schiering; Allan D'Arcy; Frederic Villard; Oliver Simic; Marion Kamke; Gaby Monnet; Ulrich Hassiepen; Dmitri I Svergun; Ruth Pulfer; Jörg Eder; Prakash Raman; Ursula Bodendorf
Journal:  Proc Natl Acad Sci U S A       Date:  2011-12-12       Impact factor: 11.205

2.  Combined X-ray, NMR, and kinetic analyses reveal uncommon binding characteristics of the hepatitis C virus NS3-NS4A protease inhibitor BI 201335.

Authors:  Christopher T Lemke; Nathalie Goudreau; Songping Zhao; Oliver Hucke; Diane Thibeault; Montse Llinàs-Brunet; Peter W White
Journal:  J Biol Chem       Date:  2011-01-26       Impact factor: 5.157

3.  In vitro resistance profile of the hepatitis C virus NS3 protease inhibitor BI 201335.

Authors:  Lisette Lagacé; Peter W White; Christiane Bousquet; Nathalie Dansereau; Florence Dô; Montse Llinas-Brunet; Martin Marquis; Marie-Josée Massariol; Roger Maurice; Catherine Spickler; Diane Thibeault; Ibtissem Triki; Songping Zhao; George Kukolj
Journal:  Antimicrob Agents Chemother       Date:  2011-10-24       Impact factor: 5.191

Review 4.  Hepatitis C virus non-structural protein 3 (HCV NS3): a multifunctional antiviral target.

Authors:  Kevin D Raney; Suresh D Sharma; Ibrahim M Moustafa; Craig E Cameron
Journal:  J Biol Chem       Date:  2010-05-10       Impact factor: 5.157

5.  Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding.

Authors:  Keith P Romano; Akbar Ali; William E Royer; Celia A Schiffer
Journal:  Proc Natl Acad Sci U S A       Date:  2010-11-17       Impact factor: 11.205

6.  In vitro resistance profile of the hepatitis C virus NS3/4A protease inhibitor TMC435.

Authors:  Oliver Lenz; Thierry Verbinnen; Tse-I Lin; Leen Vijgen; Maxwell D Cummings; Jimmy Lindberg; Jan Martin Berke; Pascale Dehertogh; Els Fransen; Annick Scholliers; Katrien Vermeiren; Tania Ivens; Pierre Raboisson; Michael Edlund; Susan Storm; Lotta Vrang; Herman de Kock; Gregory C Fanning; Kenneth A Simmen
Journal:  Antimicrob Agents Chemother       Date:  2010-02-22       Impact factor: 5.191

7.  Molecular mechanism by which a potent hepatitis C virus NS3-NS4A protease inhibitor overcomes emergence of resistance.

Authors:  Jeff A O'Meara; Christopher T Lemke; Cédrickx Godbout; George Kukolj; Lisette Lagacé; Benoît Moreau; Diane Thibeault; Peter W White; Montse Llinàs-Brunet
Journal:  J Biol Chem       Date:  2012-12-27       Impact factor: 5.157

8.  Novel Quinoline-Based P2-P4 Macrocyclic Derivatives As Pan-Genotypic HCV NS3/4a Protease Inhibitors.

Authors:  Unmesh Shah; Charles Jayne; Samuel Chackalamannil; Francisco Velázquez; Zhuyan Guo; Alexei Buevich; John A Howe; Robert Chase; Aileen Soriano; Sony Agrawal; Michael T Rudd; John A McCauley; Nigel J Liverton; Joseph Romano; Kimberly Bush; Paul J Coleman; Christiane Grisé-Bard; Marie-Christine Brochu; Sylvie Charron; Virender Aulakh; Benoit Bachand; Patrick Beaulieu; Helmi Zaghdane; Sathesh Bhat; Yongxin Han; Joseph P Vacca; Ian W Davies; Ann E Weber; Srikanth Venkatraman
Journal:  ACS Med Chem Lett       Date:  2014-01-09       Impact factor: 4.345

9.  Improving the Resistance Profile of Hepatitis C NS3/4A Inhibitors: Dynamic Substrate Envelope Guided Design.

Authors:  Ayşegül Ozen; Woody Sherman; Celia A Schiffer
Journal:  J Chem Theory Comput       Date:  2013-12-10       Impact factor: 6.006

10.  Near-Neighbor Interactions in the NS3-4A Protease of HCV Impact Replicative Fitness of Drug-Resistant Viral Variants.

Authors:  Nadezhda T Doncheva; Francisco S Domingues; David R McGivern; Tetsuro Shimakami; Stefan Zeuzem; Thomas Lengauer; Christian M Lange; Mario Albrecht; Christoph Welsch
Journal:  J Mol Biol       Date:  2019-04-30       Impact factor: 5.469
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