Literature DB >> 20165850

iTRAQ-coupled 2D LC-MS/MS analysis of secreted proteome of HBV-replicating HepG2 cells: potential in biomarkers for prognosis of HCC.

Huixing Feng1, Mingxuan Wang, Wei Ning Chen.   

Abstract

Hepatitis B virus (HBV) infection remains a major health concern with more than 350 million carriers in the world. It is associated with acute and chronic liver diseases including hepatocellular carcinoma (HCC). The early detection of severe liver diseases related to HBV is crucial for the effective treatment. This work aims to investigate the secreted proteins in our recently established cell-based HBV replication system, using isobaric tags for relative and absolute quantitation (iTRAQ)-coupled 2D LC-MS/MS proteomics approach. Such proteins are reflective of early events of HBV infection and thus may have potential as prognostic biomarkers for development of liver diseases.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20165850     DOI： 10.1007/s00284-010-9608-3

Source DB:  PubMed          Journal:  Curr Microbiol        ISSN： 0343-8651            Impact factor:   2.188


  14 in total

Review 1.  Hepatitis B virus biology.

Authors:  C Seeger; W S Mason
Journal:  Microbiol Mol Biol Rev       Date:  2000-03       Impact factor: 11.056

Review 2.  The molecular biology of the hepatitis B viruses.

Authors:  D Ganem; H E Varmus
Journal:  Annu Rev Biochem       Date:  1987       Impact factor: 23.643

3.  A cell-based system for hepatitis B virus replication: significance of clinically enhanced viral replication in relation to deletions in viral core promoter.

Authors:  Pan Hong; Lisa F P Ng; Ee Chee Ren; Wei Ning Chen
Journal:  Front Biosci       Date:  2005-09-01

4.  Comparative proteomic analysis of extracellular proteins reveals secretion of T-kininogen from vascular smooth muscle cells in response to incubation with s-enantiomer of propranolol.

Authors:  Jianjun Sui; Jianhua Zhang; Chi Bun Ching; Wei Ning Chen
Journal:  Mol Pharm       Date:  2008-06-19       Impact factor: 4.939

Review 5.  [Biomarkers in breast cancer].

Authors:  Junichi Kurebayashi
Journal:  Gan To Kagaku Ryoho       Date:  2004-07

6.  Comparative proteomics analysis of vascular smooth muscle cells incubated with S- and R-enantiomers of atenolol using iTRAQ-coupled two-dimensional LC-MS/MS.

Authors:  Jianjun Sui; Jianhua Zhang; Tuan Lin Tan; Chi Bun Ching; Wei Ning Chen
Journal:  Mol Cell Proteomics       Date:  2008-02-11       Impact factor: 5.911

7.  A strategy for the comparative analysis of serum proteomes for the discovery of biomarkers for hepatocellular carcinoma.

Authors:  Laura F Steel; Donna Shumpert; Michael Trotter; Steven H Seeholzer; Alison A Evans; W Thomas London; Raymond Dwek; Timothy M Block
Journal:  Proteomics       Date:  2003-05       Impact factor: 3.984

8.  Protein level of apolipoprotein E increased in human hepatocellular carcinoma.

Authors:  Yuichiro Yokoyama; Yasuhiro Kuramitsu; Motonari Takashima; Norio Iizuka; Shuji Terai; Masaaki Oka; Kazuyuki Nakamura; Kiwamu Okita; Isao Sakaida
Journal:  Int J Oncol       Date:  2006-03       Impact factor: 5.650

Review 9.  Contribution of oncoproteomics to cancer biomarker discovery.

Authors:  William C S Cho
Journal:  Mol Cancer       Date:  2007-04-02       Impact factor: 27.401

10.  Human serum fetuin A/alpha2HS-glycoprotein level is associated with long-term survival in patients with alcoholic liver cirrhosis, comparison with the Child-Pugh and MELD scores.

Authors:  László Kalabay; László Gráf; Krisztián Vörös; László Jakab; Zsuzsa Benko; László Telegdy; Béla Fekete; Zoltán Prohászka; George Füst
Journal:  BMC Gastroenterol       Date:  2007-03-29       Impact factor: 3.067
View more
  4 in total

1.  Identification of proteins interacting with pORF5 in the pathogenesis of C. trachomatis.

Authors:  Yan Zou; Wenting Dai; Wenbo Lei; Shengmei Su; Qiulin Huang; Zhou Zhou; Chaoqun Chen; Zhongyu Li
Journal:  Am J Transl Res       Date:  2018-06-15       Impact factor: 4.060

Review 2.  Mass spectrometry based proteomic studies on viruses and hosts--a review.

Authors:  Jie Zheng; Richard J Sugrue; Kai Tang
Journal:  Anal Chim Acta       Date:  2011-06-30       Impact factor: 6.558

3.  Quantitative proteomics analysis of early recurrence/metastasis of huge hepatocellular carcinoma following radical resection.

Authors:  Xinhui Huang; Yongyi Zeng; Xiaohua Xing; Jinhua Zeng; Yunzhen Gao; Zhixiong Cai; Bo Xu; Xiaolong Liu; Aimin Huang; Jingfeng Liu
Journal:  Proteome Sci       Date:  2014-05-01       Impact factor: 2.480

Review 4.  Applying proteomic technology to clinical virology.

Authors:  C Mancone; F Ciccosanti; C Montaldo; A B Perdomo; M Piacentini; T Alonzi; G M Fimia; M Tripodi
Journal:  Clin Microbiol Infect       Date:  2012-10-03       Impact factor: 8.067
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.